Developmental biology. Another hit for gene targeting. Wright C, Hogan B (1991) Nature 350: 458-9 Mox2 is a component of the genetic hierarchy controlling limb muscle development. Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A, Wright CV, Rigby PW, Pachnis V (1999) Nature 400: 69-73 Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R (2000) Nature 405: 966-70 Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A (1998) Cell 95: 379-91 AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR (1996) Cell 84: 321-30 Perp is a p63-regulated gene essential for epithelial integrity. Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD (2005) Cell 120: 843-56 An essential role for ectodomain shedding in mammalian development. Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, Boyce RW, Nelson N, Kozlosky CJ, Wolfson MF, Rauch CT, Cerretti DP, Paxton RJ, March CJ, Black RA (1998) Science 282: 1281-4 Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC (1995) Science 269: 230-4 The roles of retinoids in vertebrate development. Means AL, Gudas LJ (1995) Annu Rev Biochem 64: 201-33 Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Wei J, Blum S, Unger M, Jarmy G, Lamparter M, Geishauser A, Vlastos GA, Chan G, Fischer KD, Rattat D, Debatin KM, Hatzopoulos AK, Beltinger C (2004) Cancer Cell 5: 477-88 Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH, Nussbaum RL (2002) Nat Med 8: 514-7 Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA (2006) Dev Cell 11: 583-9 Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Carver RS, Stevenson MC, Scheving LA, Russell WE (2002) Gastroenterology 123: 2017-27 The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse. Muraoka RS, Sun WY, Colbert MC, Waltz SE, Witte DP, Degen JL, Friezner Degen SJ (1999) J Clin Invest 103: 1277-85 Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis. Kalluri R, Shield CF, Todd P, Hudson BG, Neilson EG (1997) J Clin Invest 99: 2470-8 A murine homolog of the yeast RNA1 gene is required for postimplantation development. DeGregori J, Russ A, von Melchner H, Rayburn H, Priyaranjan P, Jenkins NA, Copeland NG, Ruley HE (1994) Genes Dev 8: 265-76 Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA (2002) Genes Dev 16: 2650-61 Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Winnier G, Blessing M, Labosky PA, Hogan BL (1995) Genes Dev 9: 2105-16 Bmp4 is required for the generation of primordial germ cells in the mouse embryo. Lawson KA, Dunn NR, Roelen BA, Zeinstra LM, Davis AM, Wright CV, Korving JP, Hogan BL (1999) Genes Dev 13: 424-36 A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Davis AC, Wims M, Spotts GD, Hann SR, Bradley A (1993) Genes Dev 7: 671-82 Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Compton LA, Potash DA, Brown CB, Barnett JV (2007) Circ Res 101: 784-91 Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. Pelton RW, Saxena B, Jones M, Moses HL, Gold LI (1991) J Cell Biol 115: 1091-105 Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). Wall NA, Blessing M, Wright CV, Hogan BL (1993) J Cell Biol 120: 493-502 The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. Casademunt E, Carter BD, Benzel I, Frade JM, Dechant G, Barde YA (1999) EMBO J 18: 6050-61 A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. Schöler HR, Hatzopoulos AK, Balling R, Suzuki N, Gruss P (1989) EMBO J 8: 2543-50 Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. Schöler HR, Balling R, Hatzopoulos AK, Suzuki N, Gruss P (1989) EMBO J 8: 2551-7 Ultrasound backscatter microscope analysis of early mouse embryonic brain development. Turnbull DH, Bloomfield TS, Baldwin HS, Foster FS, Joyner AL (1995) Proc Natl Acad Sci U S A 92: 2239-43 Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagómez D, Van Kaer L, Wang X, Xu M (2003) Proc Natl Acad Sci U S A 100: 15782-7 Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G (1997) Proc Natl Acad Sci U S A 94: 2999-3003 Temporally compartmentalized expression of ephrin-B2 during renal glomerular development. Takahashi T, Takahashi K, Gerety S, Wang H, Anderson DJ, Daniel TO (2001) J Am Soc Nephrol 12: 2673-82 Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. Shao X, Somlo S, Igarashi P (2002) J Am Soc Nephrol 13: 1837-46 Endothelial localization of receptor tyrosine phosphatase, ECRTP/DEP-1, in developing and mature renal vasculature. Takahashi T, Takahashi K, Mernaugh R, Drozdoff V, Sipe C, Schoecklmann H, Robert B, Abrahamson DR, Daniel TO (1999) J Am Soc Nephrol 10: 2135-45 Developmental consequences of fetal exposure to drugs: what we know and what we still must learn. Ross EJ, Graham DL, Money KM, Stanwood GD (2015) Neuropsychopharmacology 40: 61-87 Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT. Ichikawa I, Kuwayama F, Pope JC, Stephens FD, Miyazaki Y (2002) Kidney Int 61: 889-98 Role of membrane-bound heparin-binding epidermal growth factor-like growth factor (HB-EGF) in renal epithelial cell branching. Takemura T, Hino S, Okada M, Murata Y, Yanagida H, Ikeda M, Yoshioka K, Harris RC (2002) Kidney Int 61: 1968-79 The role of cyclooxygenases in inflammation, cancer, and development. Williams CS, Mann M, DuBois RN (1999) Oncogene 18: 7908-16 Diverse developing mouse lineages exhibit high-level c-Myb expression in immature cells and loss of expression upon differentiation. Ess KC, Witte DP, Bascomb CP, Aronow BJ (1999) Oncogene 18: 1103-11 Optimal effectiveness of BDNF for fetal nigral transplants coincides with the ontogenic appearance of BDNF in the striatum. Yurek DM, Hipkens SB, Wiegand SJ, Altar CA (1998) J Neurosci 18: 6040-7 Maternal immune activation alters fetal brain development through interleukin-6. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH (2007) J Neurosci 27: 10695-702 Expression of transforming growth factor beta 2 RNA during murine embryogenesis. Pelton RW, Nomura S, Moses HL, Hogan BL (1989) Development 106: 759-67
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.