Keyword Connections

•  Nathan Bingham

•  Richard Simerly

•  Roger Cone

Resources

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Communities

• Cone Lab

Publications

• Obesity-associated variants within FTO form long-range functional connections with IRX3.
  Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA
  (2014) Nature 507: 371-5
• Intracellular signalling. Key enzyme in leptin-induced anorexia.
  Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW
  (2001) Nature 413: 794-5
• Neuroscience: a cellular basis for the munchies.
  Patel S, Cone RD
  (2015) Nature 519: 38-40
• Neural basis of saccade target selection in frontal eye field during visual search.
  Schall JD, Hanes DP
  (1993) Nature 366: 467-9
• Hypothalamic CART is a new anorectic peptide regulated by leptin.
  Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S
  (1998) Nature 393: 72-6
• Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
  Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK, Sulem P, Bulik-Sullivan B, Esko T, Johnson AD, Elks CE, Franceschini N, He C, Altmaier E, Brody JA, Franke LL, Huffman JE, Keller MF, McArdle PF, Nutile T, Porcu E, Robino A, Rose LM, Schick UM, Smith JA, Teumer A, Traglia M, Vuckovic D, Yao J, Zhao W, Albrecht E, Amin N, Corre T, Hottenga JJ, Mangino M, Smith AV, Tanaka T, Abecasis G, Andrulis IL, Anton-Culver H, Antoniou AC, Arndt V, Arnold AM, Barbieri C, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bernstein L, Bielinski SJ, Blomqvist C, Boerwinkle E, Bogdanova NV, Bojesen SE, Bolla MK, Borresen-Dale AL, Boutin TS, Brauch H, Brenner H, Brüning T, Burwinkel B, Campbell A, Campbell H, Chanock SJ, Chapman JR, Chen YI, Chenevix-Trench G, Couch FJ, Coviello AD, Cox A, Czene K, Darabi H, De Vivo I, Demerath EW, Dennis J, Devilee P, Dörk T, Dos-Santos-Silva I, Dunning AM, Eicher JD, Fasching PA, Faul JD, Figueroa J, Flesch-Janys D, Gandin I, Garcia ME, García-Closas M, Giles GG, Girotto GG, Goldberg MS, González-Neira A, Goodarzi MO, Grove ML, Gudbjartsson DF, Guénel P, Guo X, Haiman CA, Hall P, Hamann U, Henderson BE, Hocking LJ, Hofman A, Homuth G, Hooning MJ, Hopper JL, Hu FB, Huang J, Humphreys K, Hunter DJ, Jakubowska A, Jones SE, Kabisch M, Karasik D, Knight JA, Kolcic I, Kooperberg C, Kosma VM, Kriebel J, Kristensen V, Lambrechts D, Langenberg C, Li J, Li X, Lindström S, Liu Y, Luan J, Lubinski J, Mägi R, Mannermaa A, Manz J, Margolin S, Marten J, Martin NG, Masciullo C, Meindl A, Michailidou K, Mihailov E, Milani L, Milne RL, Müller-Nurasyid M, Nalls M, Neale BM, Nevanlinna H, Neven P, Newman AB, Nordestgaard BG, Olson JE, Padmanabhan S, Peterlongo P, Peters U, Petersmann A, Peto J, Pharoah PDP, Pirastu NN, Pirie A, Pistis G, Polasek O, Porteous D, Psaty BM, Pylkäs K, Radice P, Raffel LJ, Rivadeneira F, Rudan I, Rudolph A, Ruggiero D, Sala CF, Sanna S, Sawyer EJ, Schlessinger D, Schmidt MK, Schmidt F, Schmutzler RK, Schoemaker MJ, Scott RA, Seynaeve CM, Simard J, Sorice R, Southey MC, Stöckl D, Strauch K, Swerdlow A, Taylor KD, Thorsteinsdottir U, Toland AE, Tomlinson I, Truong T, Tryggvadottir L, Turner ST, Vozzi D, Wang Q, Wellons M, Willemsen G, Wilson JF, Winqvist R, Wolffenbuttel BBHR, Wright AF, Yannoukakos D, Zemunik T, Zheng W, Zygmunt M, Bergmann S, Boomsma DI, Buring JE, Ferrucci L, Montgomery GW, Gudnason V, Spector TD, van Duijn CM, Alizadeh BZ, Ciullo M, Crisponi L, Easton DF, Gasparini PP, Gieger C, Harris TB, Hayward C, Kardia SLR, Kraft P, McKnight B, Metspalu A, Morrison AC, Reiner AP, Ridker PM, Rotter JI, Toniolo D, Uitterlinden AG, Ulivi S, Völzke H, Wareham NJ, Weir DR, Yerges-Armstrong LM, PRACTICAL consortium, kConFab Investigators, AOCS Investigators, Generation Scotland, EPIC-InterAct Consortium, LifeLines Cohort Study, Price AL, Stefansson K, Visser JA, Ong KK, Chang-Claude J, Murabito JM, Perry JRB, Murray A
  (2015) Nat Genet 47: 1294-1303
• Leptin regulates bone formation via the sympathetic nervous system.
  Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G
  (2002) Cell 111: 305-17
• Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
  van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, INTERVAL, UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS
  (2019) Cell 176: 729-742.e18
• Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
  Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
  (2016) Nat Med 22: 800-6
• Glucagon's yin and yang effects on hepatic glucose production.
  Edgerton DS, Cherrington AD
  (2013) Nat Med 19: 674-5
• Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.
  Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD
  (2004) Nat Neurosci 7: 335-6
• Anatomy and regulation of the central melanocortin system.
  Cone RD
  (2005) Nat Neurosci 8: 571-8
• Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
  Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW
  (2005) Cell Metab 2: 411-20
• AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.
  Zhang C, Forlano PM, Cone RD
  (2012) Cell Metab 15: 256-64
• PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors.
  Ghamari-Langroudi M, Colmers WF, Cone RD
  (2005) Cell Metab 2: 191-9
• Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
  Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ
  (2009) J Clin Invest 119: 2577-89
• Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.
  Ghamari-Langroudi M, Srisai D, Cone RD
  (2011) Proc Natl Acad Sci U S A 108: 355-60
• Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis.
  Niswender KD, Baskin DG, Schwartz MW
  (2004) Trends Endocrinol Metab 15: 362-9
• Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities.
  Niswender KD, Schwartz MW
  (2003) Front Neuroendocrinol 24: 1-10
• Interaction between the central and peripheral effects of insulin in controlling hepatic glucose metabolism in the conscious dog.
  Ramnanan CJ, Kraft G, Smith MS, Farmer B, Neal D, Williams PE, Lautz M, Farmer T, Donahue EP, Cherrington AD, Edgerton DS
  (2013) Diabetes 62: 74-84
• Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia.
  Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG, Seeley RJ, Schwartz MW
  (2003) Diabetes 52: 227-31
• The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice.
  Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE
  (2017) Diabetes 66: 372-384
• Hypothalamic peptidyl-glycine alpha-amidating monooxygenase: preliminary characterization.
  Emeson RB
  (1984) J Neurosci 4: 2604-13
• Characterization of pro-ACTH/endorphin-derived peptides in rat hypothalamus.
  Emeson RB, Eipper BA
  (1986) J Neurosci 6: 837-49
• The melanocortin-3 receptor is required for entrainment to meal intake.
  Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA
  (2008) J Neurosci 28: 12946-55
• The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol.
  Lagrange AH, Ronnekleiv OK, Kelly MJ
  (1994) J Neurosci 14: 6196-204
• The effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopause.
  Abel TW, Voytko ML, Rance NE
  (1999) J Clin Endocrinol Metab 84: 2111-8
• Ovarian steroids differentially modulate the gene expression of gonadotropin-releasing hormone neuronal subtypes in the ovariectomized cynomolgus monkey.
  Krajewski SJ, Abel TW, Voytko ML, Rance NE
  (2003) J Clin Endocrinol Metab 88: 655-62
• The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex.
  Labosky PA, Winnier GE, Jetton TL, Hargett L, Ryan AK, Rosenfeld MG, Parlow AF, Hogan BL
  (1997) Development 124: 1263-74
• Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.
  Morabito MV, Abbas AI, Hood JL, Kesterson RA, Jacobs MM, Kump DS, Hachey DL, Roth BL, Emeson RB
  (2010) Neurobiol Dis 39: 169-80
• Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.
  Hohenadel MG, Thearle MS, Grice BA, Huang H, Dai MH, Tao YX, Hunter LA, Palaguachi GI, Mou Z, Kim RC, Tsang MM, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Muller YL, Baier LJ, Krakoff J, Knowler WC, Yanovski JA, Han JC
  (2014) Int J Obes (Lond) 38: 1068-74
• Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.
  Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD
  (2010) Mol Endocrinol 24: 2366-81
• Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress.
  Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE
  (1994) Mol Endocrinol 8: 240-8
• Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice.
  Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE
  (1994) Mol Endocrinol 8: 116-25
• Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
  Halatchev IG, Ellacott KL, Fan W, Cone RD
  (2004) Endocrinology 145: 2585-90
• Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state.
  Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M
  (2010) Endocrinology 151: 2200-10
• Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
  Morton GJ, Niswender KD, Rhodes CJ, Myers MG, Blevins JE, Baskin DG, Schwartz MW
  (2003) Endocrinology 144: 2016-24
• Characterization of leptin-responsive neurons in the caudal brainstem.
  Ellacott KL, Halatchev IG, Cone RD
  (2006) Endocrinology 147: 3190-5