In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M (2013) Cancer Cell 23: 660-76 Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A (2011) Neuron 71: 250-62 Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD (2016) Nat Neurosci 19: 243-52 The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Fleming JT, He W, Hao C, Ketova T, Pan FC, Wright CC, Litingtung Y, Chiang C (2013) Dev Cell 27: 278-92 Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development. Moon KH, Kim HT, Lee D, Rao MB, Levine EM, Lim DS, Kim JW (2018) Dev Cell 44: 13-28.e3 Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells. Dirian L, Galant S, Coolen M, Chen W, Bedu S, Houart C, Bally-Cuif L, Foucher I (2014) Dev Cell 30: 123-36 Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH (2012) Proc Natl Acad Sci U S A 109: 8710-5 Lost their ways? Brown JA, Mirnics K (2013) Biol Psychiatry 74: 398-9 A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease. Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB (2015) Hum Mol Genet 24: 1929-44 YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM (2016) Oncogene 35: 4256-68 WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Wen J, Lee J, Malhotra A, Nahta R, Arnold AR, Buss MC, Brown BD, Maier C, Kenney AM, Remke M, Ramaswamy V, Taylor MD, Castellino RC (2016) Oncogene 35: 5552-5564 Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. Crowther AJ, Gama V, Bevilacqua A, Chang SX, Yuan H, Deshmukh M, Gershon TR (2013) J Neurosci 33: 18098-108 The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen. Garcia ADR, Han YG, Triplett JW, Farmer WT, Harwell CC, Ihrie RA (2018) J Neurosci 38: 9338-9345 Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. Gordon PJ, Yun S, Clark AM, Monuki ES, Murtaugh LC, Levine EM (2013) J Neurosci 33: 12197-207 Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Mundell NA, Labosky PA (2011) Development 138: 641-52 Sonic hedgehog signaling in the postnatal brain. Álvarez-Buylla A, Ihrie RA (2014) Semin Cell Dev Biol 33: 105-11 PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Aboud AA, Tidball AM, Kumar KK, Neely MD, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB (2015) Neurobiol Dis 73: 204-12 Space Invaders: Brain Tumor Exploitation of the Stem Cell Niche. Sinnaeve J, Mobley BC, Ihrie RA (2018) Am J Pathol 188: 29-38 DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB (2012) ACS Chem Neurosci 3: 482-91 Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture. Cheng FY, Fleming JT, Chiang C (2018) Dev Biol 440: 152-166 Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development. Wu SY, de Borsetti NH, Bain EJ, Bulow CR, Gamse JT (2014) Dev Biol 385: 13-22 Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis. Mobley BC, Kwon M, Kraemer BR, Hickman FE, Qiao J, Chung DH, Carter BD (2015) PLoS One 10: e0133897 Male-specific differences in proliferation, neurogenesis, and sensitivity to oxidative stress in neural progenitor cells derived from a rat model of ALS. Li R, Strykowski R, Meyer M, Mulcrone P, Krakora D, Suzuki M (2012) PLoS One 7: e48581 Genetic chimeras reveal the autonomy requirements for Vsx2 in embryonic retinal progenitor cells. Sigulinsky CL, German ML, Leung AM, Clark AM, Yun S, Levine EM (2015) Neural Dev 10: 12 A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Lippmann ES, Al-Ahmad A, Azarin SM, Palecek SP, Shusta EV (2014) Sci Rep 4: 4160 Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line. Bryan MR, Uhouse MA, Nordham KD, Joshi P, Rose DIR, O'Brien MT, Aschner M, Bowman AB (2018) Neurotoxicology 64: 185-194 Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects. Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB (2012) Neurotoxicology 33: 1443-1449 Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Müller glia-derived neuronal progenitor cells. Rajaram K, Harding RL, Bailey T, Patton JG, Hyde DR (2014) Dev Dyn 243: 1591-605 Conditional and domain-specific inactivation of the Tsc2 gene in neural progenitor cells. Fu C, Ess KC (2013) Genesis 51: 284-92 Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L (2012) Genesis 50: 612-24 Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance. Dellett M, Hu W, Papadaki V, Ohnuma S (2012) Dev Growth Differ 54: 327-40 Insm1 promotes neurogenic proliferation in delaminated otic progenitors. Lorenzen SM, Duggan A, Osipovich AB, Magnuson MA, García-Añoveros J (2015) Mech Dev 138 Pt 3: 233-45 Technical brief: Constant intense light exposure to lesion and initiate regeneration in normally pigmented zebrafish. Rajaram K, Summerbell ER, Patton JG (2014) Mol Vis 20: 1075-84
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.