In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) Nature 455: 627-32 Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D (2012) Nat Genet 44: 406-12, S1 Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H (2014) Nat Biotechnol 32: 76-83 Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW (2016) Nat Med 22: 800-6 Regulation of net hepatic glucose uptake in vivo. Pagliassotti MJ, Cherrington AD (1992) Annu Rev Physiol 54: 847-60 High normal fasting blood glucose is associated with dementia in Chinese elderly. Mortimer JA, Borenstein AR, Ding D, Decarli C, Zhao Q, Copenhaver C, Guo Q, Chu S, Galasko D, Salmon DP, Dai Q, Wu Y, Petersen R, Hong Z (2010) Alzheimers Dement 6: 440-7 Effect of glucagon on glucose production during insulin deficiency in the dog. Cherrington AD, Lacy WW, Chiasson JL (1978) J Clin Invest 62: 664-77 Effects of morphine on glucose homeostasis in the conscious dog. Radosevich PM, Williams PE, Lacy DB, McRae JR, Steiner KE, Cherrington AD, Lacy WW, Abumrad NN (1984) J Clin Invest 74: 1473-80 Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L (2012) J Clin Invest 122: 3516-28 Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. Shulman GI, Lacy WW, Liljenquist JE, Keller U, Williams PE, Cherrington AD (1980) J Clin Invest 65: 496-505 Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams KW, Xu Y, Elmquist JK (2013) J Clin Invest 123: 5061-70 EGF receptor deletion in podocytes attenuates diabetic nephropathy. Chen J, Chen JK, Harris RC (2015) J Am Soc Nephrol 26: 1115-25 The amino acid-induced alteration in renal hemodynamics is glucagon independent. Nammour TM, Williams PE, Badr KF, Abumrad NN, Jacobson HR (1991) J Am Soc Nephrol 2: 164-71 Glucose toxicity is responsible for the development of impaired regulation of endogenous glucose production and hepatic glucokinase in Zucker diabetic fatty rats. Fujimoto Y, Torres TP, Donahue EP, Shiota M (2006) Diabetes 55: 2479-90 Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups. Freathy RM, Hayes MG, Urbanek M, Lowe LP, Lee H, Ackerman C, Frayling TM, Cox NJ, Dunger DB, Dyer AR, Hattersley AT, Metzger BE, Lowe WL, HAPO Study Cooperative Research Group (2010) Diabetes 59: 2682-9 β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B (2013) Diabetes 62: 1527-36 Alpha- and beta-cell responses to small changes in plasma glucose in the conscious dog. Flattem N, Igawa K, Shiota M, Emshwiller MG, Neal DW, Cherrington AD (2001) Diabetes 50: 367-75 Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone. Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, Screaton RA, Poitout V, Ferron M, Alquier T, Estall JL (2015) Diabetes 64: 3798-807 Hepatic glucose metabolism in late pregnancy: normal versus high-fat and -fructose diet. Coate KC, Smith MS, Shiota M, Irimia JM, Roach PJ, Farmer B, Williams PE, Moore MC (2013) Diabetes 62: 753-61 A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose. Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (2010) Diabetes 59: 539-49 Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M (2009) Diabetes 58: 78-86 Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Coate KC, Kraft G, Irimia JM, Smith MS, Farmer B, Neal DW, Roach PJ, Shiota M, Cherrington AD (2013) Diabetes 62: 392-400 Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells. Paul L, Walker EM, Drosos Y, Cyphert HA, Neale G, Stein R, South J, Grosveld G, Herrera PL, Sosa-Pineda B (2016) Diabetes 65: 687-98 Defective glycogenesis contributes toward the inability to suppress hepatic glucose production in response to hyperglycemia and hyperinsulinemia in zucker diabetic fatty rats. Torres TP, Fujimoto Y, Donahue EP, Printz RL, Houseknecht KL, Treadway JL, Shiota M (2011) Diabetes 60: 2225-33 Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog. Shiota M, Moore MC, Galassetti P, Monohan M, Neal DW, Shulman GI, Cherrington AD (2002) Diabetes 51: 469-78 Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA (2011) Diabetes 60: 827-37 The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months. Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP, Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups (2015) Diabetes Care 38: 940-2 Diabetes referrals at a Veterans Administration tertiary facility: who are the patients and why are they referred? Nguyen CV, Powers AC, Greenspan DL, Elasy TA (2005) Diabetes Care 28: 423-4 Preventing glycaemic relapse in recently controlled type 2 diabetes patients: a randomised controlled trial. Huizinga MM, Gebretsadik T, Garcia Ulen C, Shintani AK, Michon SR, Shackleford LO, Wolff KL, Brown AW, Rothman RL, Elasy TA (2010) Diabetologia 53: 832-9 A non-mammalian in vivo model for cellular and molecular analysis of glucose-mediated thickening of basement membranes. Zhang X, Huff JK, Hudson BG, Sarras MP (1990) Diabetologia 33: 704-7 A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function. Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL (2008) Diabetologia 51: 1449-56 Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man. Liljenquist JE, Bloomgarden ZT, Cherrington AD, Perry JM, Rabin D (1979) Diabetologia 17: 139-43 Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource. Liu CT, Ng MC, Rybin D, Adeyemo A, Bielinski SJ, Boerwinkle E, Borecki I, Cade B, Chen YD, Djousse L, Fornage M, Goodarzi MO, Grant SF, Guo X, Harris T, Kabagambe E, Kizer JR, Liu Y, Lunetta KL, Mukamal K, Nettleton JA, Pankow JS, Patel SR, Ramos E, Rasmussen-Torvik L, Rich SS, Rotimi CN, Sarpong D, Shriner D, Sims M, Zmuda JM, Redline S, Kao WH, Siscovick D, Florez JC, Rotter JI, Dupuis J, Wilson JG, Bowden DW, Meigs JB (2012) Diabetologia 55: 2970-84 Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice. Luo P, Dematteo A, Wang Z, Zhu L, Wang A, Kim HS, Pozzi A, Stafford JM, Luther JM (2013) Diabetologia 56: 901-10 Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Davis EA, Cuesta-Muñoz A, Raoul M, Buettger C, Sweet I, Moates M, Magnuson MA, Matschinsky FM (1999) Diabetologia 42: 1175-86 Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC (2012) Diabetologia 55: 707-18 Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. Liljenquist JE, Mueller GL, Cherrington AD, Perry JM, Rabinowitz D (1979) J Clin Endocrinol Metab 48: 171-5 Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans. Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ (2014) J Clin Endocrinol Metab 99: E1895-902 Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning. Yin D, Ding JW, Shen J, Ma L, Hara M, Chong AS (2006) Am J Transplant 6: 60-8 Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice. Brehm MA, Powers AC, Shultz LD, Greiner DL (2012) Cold Spring Harb Perspect Med 2: a007757
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