Factor XI antisense oligonucleotide for prevention of venous thrombosis. Büller HR, Bethune C, Bhanot S, Gailani D, Monia BP, Raskob GE, Segers A, Verhamme P, Weitz JI, FXI-ASO TKA Investigators (2015) N Engl J Med 372: 232-40 The index case for the fungal meningitis outbreak in the United States. Pettit AC, Kropski JA, Castilho JL, Schmitz JE, Rauch CA, Mobley BC, Wang XJ, Spires SS, Pugh ME (2012) N Engl J Med 367: 2119-25 Efficacy and safety of recombinant human activated protein C for severe sepsis. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group (2001) N Engl J Med 344: 699-709 Syk tyrosine kinase required for mouse viability and B-cell development. Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T (1995) Nature 378: 303-6 Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE (2016) Cell 164: 392-405 A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses. Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE, Aman MJ, Dye JM, Lai JR, Chandran K (2016) Science 354: 350-354 Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance. Love PE, Santoro SA (1990) Ann Intern Med 112: 682-98 Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study. Ray WA, Murray KT, Griffin MR, Chung CP, Smalley WE, Hall K, Daugherty JR, Kaltenbach LA, Stein CM (2010) Ann Intern Med 152: 337-45 Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Griffin MR, Ray WA, Schaffner W (1988) Ann Intern Med 109: 359-63 Defective thrombus formation in mice lacking coagulation factor XII. Renné T, Pozgajová M, Grüner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B (2005) J Exp Med 202: 271-81 Elimination of Helicobacter pylori or acid in high-risk users of aspirin or nonsteroidal medications: final answer? Peek RM (2002) Gastroenterology 122: 238-40 p120-Catenin is required for mouse vascular development. Oas RG, Xiao K, Summers S, Wittich KB, Chiasson CM, Martin WD, Grossniklaus HE, Vincent PA, Reynolds AB, Kowalczyk AP (2010) Circ Res 106: 941-51 Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding. Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR (2011) Blood 118: 5302-11 Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting. Martincic D, Zimmerman SA, Ware RE, Sun MF, Whitlock JA, Gailani D (1998) Blood 92: 3309-17 A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity. Brooks MB, Catalfamo JL, Brown HA, Ivanova P, Lovaglio J (2002) Blood 99: 2434-41 Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/hemorrhagic risk. Santoro SA (1999) Blood 93: 3575-7 Central nervous system complications and management in sickle cell disease. DeBaun MR, Kirkham FJ (2016) Blood 127: 829-38 Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB (2012) Thorax 67: 1032-9 Studies of gastric ulcer disease by community-based gastroenterologists. Brazer SR, Tyor MP, Pancotto FS, Nickl NJ, Wildermann NM, Harrell FE, Pryor DB (1990) Am J Gastroenterol 85: 824-8 Are isofurans and neuroprostanes increased after subarachnoid hemorrhage and traumatic brain injury? Corcoran TB, Mas E, Barden AE, Durand T, Galano JM, Roberts LJ, Phillips M, Ho KM, Mori TA (2011) Antioxid Redox Signal 15: 2663-7 Contribution of endogenous bradykinin to fibrinolysis, inflammation, and blood product transfusion following cardiac surgery: a randomized clinical trial. Balaguer JM, Yu C, Byrne JG, Ball SK, Petracek MR, Brown NJ, Pretorius M (2013) Clin Pharmacol Ther 93: 326-34 Factor XI as a target for antithrombotic therapy. Bane CE, Gailani D (2014) Drug Discov Today 19: 1454-8 Haemosiderin-laden macrophages in the bronchoalveolar lavage fluid of patients with diffuse alveolar damage. Maldonado F, Parambil JG, Yi ES, Decker PA, Ryu JH (2009) Eur Respir J 33: 1361-6 Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates. Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP (2013) Arterioscler Thromb Vasc Biol 33: 1670-8 Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. Yamakawa Y, Takano M, Patel M, Tien N, Takada T, Bulkley GB (2000) Ann Surg 231: 387-98 Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Ely EW, Laterre PF, Angus DC, Helterbrand JD, Levy H, Dhainaut JF, Vincent JL, Macias WL, Bernard GR, PROWESS Investigators (2003) Crit Care Med 31: 12-9 Sirolimus-associated diffuse alveolar hemorrhage. Vlahakis NE, Rickman OB, Morgenthaler T (2004) Mayo Clin Proc 79: 541-5 Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies. Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EO (2016) MBio 7: e02154-15 A 12-year-old girl with pulmonary hemorrhage, skin lesions, and hematuria. Paueksakon P, Hunley TE, Lee SM, Fogo AB (1999) Am J Kidney Dis 33: 404-9 Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes. Sarkiss MG, Yusuf SW, Warneke CL, Botz G, Lakkis N, Hirch-Ginsburg C, Champion JC, Swafford J, Shaw AD, Lenihan DJ, Durand JB (2007) Cancer 109: 621-7 Influence of hemorrhagic shock followed by crystalloid resuscitation on propofol: a pharmacokinetic and pharmacodynamic analysis. Johnson KB, Egan TD, Kern SE, McJames SW, Cluff ML, Pace NL (2004) Anesthesiology 101: 647-59 Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. Strouse JJ, Hulbert ML, DeBaun MR, Jordan LC, Casella JF (2006) Pediatrics 118: 1916-24 Safety and efficacy of regional citrate anticoagulation during 8-hour sustained low-efficiency dialysis. Clark JA, Schulman G, Golper TA (2008) Clin J Am Soc Nephrol 3: 736-42 A cross-sectional study of bleeding phenotype in haemophilia A carriers. Paroskie A, Gailani D, DeBaun MR, Sidonio RF (2015) Br J Haematol 170: 223-8 Self-reported heavy bleeding associated with uterine leiomyomata. Wegienka G, Baird DD, Hertz-Picciotto I, Harlow SD, Steege JF, Hill MC, Schectman JM, Hartmann KE (2003) Obstet Gynecol 101: 431-7 Vaginal bleeding during pregnancy and preterm birth. Yang J, Hartmann KE, Savitz DA, Herring AH, Dole N, Olshan AF, Thorp JM (2004) Am J Epidemiol 160: 118-25 Nonsteroidal anti-inflammatory drugs and the incidence of hospitalizations for peptic ulcer disease in elderly persons. Smalley WE, Ray WA, Daugherty JR, Griffin MR (1995) Am J Epidemiol 141: 539-45 An IgG inhibitor against coagulation factor XIII: resolution of bleeding after plasma immunoadsorption with staphylococcal protein A. Gailani D (1992) Am J Med 92: 110-2 First-trimester bleeding characteristics associate with increased risk of preterm birth: data from a prospective pregnancy cohort. Velez Edwards DR, Baird DD, Hasan R, Savitz DA, Hartmann KE (2012) Hum Reprod 27: 54-60
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.