Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N (2006) Cell Metab 4: 143-54 Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ (2009) J Clin Invest 119: 2577-89 Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. Goodwin JS, Drake KR, Rogers C, Wright L, Lippincott-Schwartz J, Philips MR, Kenworthy AK (2005) J Cell Biol 170: 261-72 Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, Bredt DS (2000) J Cell Biol 148: 159-72 Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA (1992) Proc Natl Acad Sci U S A 89: 10930-4 The role of dynamic palmitoylation in Ca2+ channel inactivation. Hurley JH, Cahill AL, Currie KP, Fox AP (2000) Proc Natl Acad Sci U S A 97: 9293-8 Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N (2008) Diabetes 57: 2382-92 Hydrophobic interactions between polymeric carrier and palmitic acid-conjugated siRNA improve PEGylated polyplex stability and enhance in vivo pharmacokinetics and tumor gene silencing. Sarett SM, Werfel TA, Chandra I, Jackson MA, Kavanaugh TE, Hattaway ME, Giorgio TD, Duvall CL (2016) Biomaterials 97: 122-32 P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1. Mirnics ZK, Yan C, Portugal C, Kim TW, Saragovi HU, Sisodia SS, Mirnics K, Schor NF (2005) Neurobiol Dis 20: 969-85 Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Kanner SB, Reynolds AB, Parsons JT (1991) Mol Cell Biol 11: 713-20 Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress. Hill MN, Miller GE, Carrier EJ, Gorzalka BB, Hillard CJ (2009) Psychoneuroendocrinology 34: 1257-62 Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. Camp LA, Hofmann SL (1993) J Biol Chem 268: 22566-74 Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis. Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G (2009) J Biol Chem 284: 33425-36 Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux. Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD (2019) J Biol Chem 294: 3081-3090 Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes. Guengerich FP, Wilkey CJ, Phan TTN (2019) J Biol Chem 294: 10928-10941 Splanchnic free fatty acid kinetics. Jensen MD, Cardin S, Edgerton D, Cherrington A (2003) Am J Physiol Endocrinol Metab 284: E1140-8 Human lactation: maternal transfer of dietary triglycerides labeled with stable isotopes. Hachey DL, Thomas MR, Emken EA, Garza C, Brown-Booth L, Adlof RO, Klein PD (1987) J Lipid Res 28: 1185-92 Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. Lin DS, Connor WE, Wolf DP, Neuringer M, Hachey DL (1993) J Lipid Res 34: 491-9 Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD (2014) J Lipid Res 55: 1478-88 The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ (2005) J Lipid Res 46: 342-9 Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. Endocannabinoid Research Group, De Filippis D, D'Amico A, Cipriano M, Petrosino S, Orlando P, Di Marzo V, Iuvone T (2010) Pharmacol Res 61: 321-8 Hepatic TLR4 signaling in obese NAFLD. Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR (2015) Am J Physiol Gastrointest Liver Physiol 309: G270-8 Fluorescence-based methods to image palmitoylated proteins. Kenworthy AK (2006) Methods 40: 198-205 Thiol-fatty acylation of the glucose transport protein of human erythrocytes. May JM (1990) FEBS Lett 274: 119-21 Proteomic Analysis of S-Palmitoylated Proteins in Ocular Lens Reveals Palmitoylation of AQP5 and MP20. Wang Z, Schey KL (2018) Invest Ophthalmol Vis Sci 59: 5648-5658 Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs. Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG (2014) Arch Biochem Biophys 546: 33-40 The interaction between nutritional status and growth hormone in young cattle: differential responsiveness of fat and protein metabolism. Dawson JM, Greathead HM, Craigon J, Hachey DL, Reeds PJ, Pell JM, Buttery PJ (1998) Br J Nutr 79: 275-86 Uptake and utilization of metabolites in specific brain sites relative to feeding status. Kasser TR, Deutch A, Martin RJ (1986) Physiol Behav 36: 1161-5 Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes. Egnatchik RA, Leamy AK, Noguchi Y, Shiota M, Young JD (2014) Metabolism 63: 283-95 The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis. Capozzi ME, Savage SR, McCollum GW, Hammer SS, Ramos CJ, Yang R, Bretz CA, Penn JS (2020) Exp Eye Res 190: 107885 Palmitic Acid Induces Müller Cell Inflammation that is Potentiated by Co-treatment with Glucose. Capozzi ME, Giblin MJ, Penn JS (2018) Sci Rep 8: 5459 Conjugation of palmitic acid improves potency and longevity of siRNA delivered via endosomolytic polymer nanoparticles. Sarett SM, Kilchrist KV, Miteva M, Duvall CL (2015) J Biomed Mater Res A 103: 3107-16
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.