Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ (2011) Mol Psychiatry 16: 569-81 Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults. Fabbrini E, Tamboli RA, Magkos F, Marks-Shulman PA, Eckhauser AW, Richards WO, Klein S, Abumrad NN (2010) Gastroenterology 139: 448-55 Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD (2009) J Clin Invest 119: 573-81 Circadian disruption leads to insulin resistance and obesity. Shi SQ, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH (2013) Curr Biol 23: 372-81 The amino acid-induced alteration in renal hemodynamics is glucagon independent. Nammour TM, Williams PE, Badr KF, Abumrad NN, Jacobson HR (1991) J Am Soc Nephrol 2: 164-71 Lost in translation. Wasserman DH, Ayala JE, McGuinness OP (2009) Diabetes 58: 1947-50 Relationship between decrements in glucose level and metabolic response to hypoglycemia in absence of counterregulatory hormones in the conscious dog. Connolly CC, Adkins-Marshall BA, Neal DW, Pugh W, Jaspan JB, Cherrington AD (1992) Diabetes 41: 1308-19 Estrogen treatment after ovariectomy protects against fatty liver and may improve pathway-selective insulin resistance. Zhu L, Brown WC, Cai Q, Krust A, Chambon P, McGuinness OP, Stafford JM (2013) Diabetes 62: 424-34 The effects of differing insulin levels on the hormonal and metabolic response to equivalent hypoglycemia in normal humans. Davis SN, Goldstein RE, Jacobs J, Price L, Wolfe R, Cherrington AD (1993) Diabetes 42: 263-72 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. Pencek RR, Shearer J, Camacho RC, James FD, Lacy DB, Fueger PT, Donahue EP, Snead W, Wasserman DH (2005) Diabetes 54: 355-60 Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II. Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH (2007) Diabetes 56: 2476-84 Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice. Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Granner DK, Wasserman DH (2004) Diabetes 53: 306-14 SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat-Fed Mice. Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH (2015) Diabetes 64: 3081-92 Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo. Edgerton DS, Ramnanan CJ, Grueter CA, Johnson KM, Lautz M, Neal DW, Williams PE, Cherrington AD (2009) Diabetes 58: 2766-75 Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog. Shiota M, Galassetti P, Monohan M, Neal DW, Cherrington AD (1998) Diabetes 47: 867-73 β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion. Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B (2013) Diabetes 62: 1527-36 Insulin action in the double incretin receptor knockout mouse. Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ (2008) Diabetes 57: 288-97 Effects of Antecedent GABA A Receptor Activation on Counterregulatory Responses to Exercise in Healthy Man. Hedrington MS, Tate DB, Younk LM, Davis SN (2015) Diabetes 64: 3253-61 Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Højlund K, Yi Z, Mandarino LJ (2010) Diabetes 59: 33-42 Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Ayala JE, Bracy DP, McGuinness OP, Wasserman DH (2006) Diabetes 55: 390-7 AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide. Shearer J, Fueger PT, Vorndick B, Bracy DP, Rottman JN, Clanton JA, Wasserman DH (2004) Diabetes 53: 1429-35 Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH (2007) Diabetes 56: 1025-33 Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. Camacho RC, Pencek RR, Lacy DB, James FD, Donahue EP, Wasserman DH (2005) Diabetes 54: 373-82 Prevention of overt hypoglycemia during exercise: stimulation of endogenous glucose production independent of hepatic catecholamine action and changes in pancreatic hormone concentration. Coker RH, Koyama Y, Denny JC, Camacho RC, Lacy DB, Wasserman DH (2002) Diabetes 51: 1310-8 Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Pozzi A, Zutter MM, Wasserman DH (2011) Diabetes 60: 416-26 Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension. Cook S, Hugli O, Egli M, Ménard B, Thalmann S, Sartori C, Perrin C, Nicod P, Thorens B, Vollenweider P, Scherrer U, Burcelin R (2004) Diabetes 53: 2067-72 Glucose metabolism in vivo in four commonly used inbred mouse strains. Berglund ED, Li CY, Poffenberger G, Ayala JE, Fueger PT, Willis SE, Jewell MM, Powers AC, Wasserman DH (2008) Diabetes 57: 1790-9 Direct and indirect effects of insulin on glucose uptake and storage by the liver. Satake S, Moore MC, Igawa K, Converse M, Farmer B, Neal DW, Cherrington AD (2002) Diabetes 51: 1663-71 Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver. Pencek RR, James FD, Lacy DB, Jabbour K, Williams PE, Fueger PT, Wasserman DH (2004) Diabetes 53: 3041-7 Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ (2007) Diabetes 56: 1508-16 Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB (2004) Diabetes 53: 336-46 Hepatic and peripheral insulin sensitivity and diabetes remission at 1 month after Roux-en-Y gastric bypass surgery in patients randomized to omentectomy. Dunn JP, Abumrad NN, Breitman I, Marks-Shulman PA, Flynn CR, Jabbour K, Feurer ID, Tamboli RA (2012) Diabetes Care 35: 137-42 Chronic Angiotensin-(1-7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure. Williams IM, Otero YF, Bracy DP, Wasserman DH, Biaggioni I, Arnold AC (2016) Hypertension 67: 983-91 Autonomic blockade improves insulin sensitivity in obese subjects. Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR, Paranjape SY, Farley G, Abumrad N, Biaggioni I (2014) Hypertension 64: 867-74 Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH (2014) Diabetologia 57: 603-13 Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice. Luo P, Dematteo A, Wang Z, Zhu L, Wang A, Kim HS, Pozzi A, Stafford JM, Luther JM (2013) Diabetologia 56: 901-10 Kidney function, β-cell function and glucose tolerance in older men. Jia T, Risérus U, Xu H, Lindholm B, Ärnlöv J, Sjögren P, Cederholm T, Larsson TE, Ikizler TA, Carrero JJ (2015) J Clin Endocrinol Metab 100: 587-93 Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA (2015) J Clin Endocrinol Metab 100: 4533-40 Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes. Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A (2013) J Clin Endocrinol Metab 98: E1780-5 Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans. Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ (2014) J Clin Endocrinol Metab 99: E1895-902
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.