In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008) Nature 455: 627-32 Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5. de Bruin RA, McDonald WH, Kalashnikova TI, Yates J, Wittenberg C (2004) Cell 117: 887-98 Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V (1997) Science 277: 225-8 Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CV, Kawaguchi Y, Nakao K, Nabeshima Y (2005) Neuron 47: 201-13 Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY (2012) Genes Dev 26: 1780-96 Exaggerated left ventricular dilation and reduced collagen deposition after myocardial infarction in mice lacking osteopontin. Trueblood NA, Xie Z, Communal C, Sam F, Ngoy S, Liaw L, Jenkins AW, Wang J, Sawyer DB, Bing OH, Apstein CS, Colucci WS, Singh K (2001) Circ Res 88: 1080-7 Functional design in the actin cytoskeleton. Small JV, Rottner K, Kaverina I (1999) Curr Opin Cell Biol 11: 54-60 A novel role for p120 catenin in E-cadherin function. Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB (2002) J Cell Biol 159: 465-76 Microtubule targeting of substrate contacts promotes their relaxation and dissociation. Kaverina I, Krylyshkina O, Small JV (1999) J Cell Biol 146: 1033-44 Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M (2011) Proc Natl Acad Sci U S A 108: 15242-7 Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta. Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M (2002) Proc Natl Acad Sci U S A 99: 3818-23 K-Cl cotransporters, cell volume homeostasis, and neurological disease. Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E (2015) Trends Mol Med 21: 513-23 Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Kumar A, Lawrence JC, Jung DY, Ko HJ, Keller SR, Kim JK, Magnuson MA, Harris TE (2010) Diabetes 59: 1397-406 Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA (2011) Diabetes 60: 827-37 Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1. Ackermann Misfeldt A, Costa RH, Gannon M (2008) Diabetes 57: 3069-77 Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL (2003) Hum Mol Genet 12: 1981-93 Rapid spreading and mature hemidesmosome formation in HaCaT keratinocytes induced by incubation with soluble laminin-5r. Hormia M, Falk-Marzillier J, Plopper G, Tamura RN, Jones JC, Quaranta V (1995) J Invest Dermatol 105: 557-61 Src induces morphological changes in A431 cells that resemble epidermal differentiation through an SH3- and Ras-independent pathway. Jin F, Reynolds AB, Hines MD, Jensen PJ, Johnson KR, Wheelock MJ (1999) J Cell Sci 112 ( Pt 17): 2913-24 The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility. Faix J, Clougherty C, Konzok A, Mintert U, Murphy J, Albrecht R, Mühlbauer B, Kuhlmann J (1998) J Cell Sci 111 ( Pt 20): 3059-71 p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL (2002) J Cell Sci 115: 3193-206 Coordinated maintenance of muscle cell size control by AMP-activated protein kinase. Lantier L, Mounier R, Leclerc J, Pende M, Foretz M, Viollet B (2010) FASEB J 24: 3555-61 Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V (2004) FASEB J 18: 364-6 Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Kim SH, Speirs CK, Solnica-Krezel L, Ess KC (2011) Dis Model Mech 4: 255-67 Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M (2009) Mol Endocrinol 23: 324-36 The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M (2006) Mol Endocrinol 20: 1853-66 Titin determines the Frank-Starling relation in early diastole. Helmes M, Lim CC, Liao R, Bharti A, Cui L, Sawyer DB (2003) J Gen Physiol 121: 97-110 GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel. Denton J, Nehrke K, Yin X, Morrison R, Strange K (2005) J Gen Physiol 125: 113-25 Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy. Plank JL, Frist AY, LeGrone AW, Magnuson MA, Labosky PA (2011) Endocrinology 152: 4589-600 The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice. Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM (2016) Endocrinology 157: 220-32 Functional characterization of domains contained in hepatocyte growth factor-like protein. Waltz SE, McDowell SA, Muraoka RS, Air EL, Flick LM, Chen YQ, Wang MH, Degen SJ (1997) J Biol Chem 272: 30526-37 Expression of matrix metalloprotease-2-cleaved laminin-5 in breast remodeling stimulated by sex steroids. Giannelli G, Pozzi A, Stetler-Stevenson WG, Gardner HA, Quaranta V (1999) Am J Pathol 154: 1193-201 Automated quantification of pancreatic β-cell mass. Golson ML, Bush WS, Brissova M (2014) Am J Physiol Endocrinol Metab 306: E1460-7 Stereologic study of the hypothalamic infundibular nucleus in young and older women. Abel TW, Rance NE (2000) J Comp Neurol 424: 679-88 Morphological identification of ganglion cells expressing the alpha subunit of type II calmodulin-dependent protein kinase in the macaque retina. Calkins DJ, Sappington RM, Hendry SH (2005) J Comp Neurol 481: 194-209 Taxol-treated fibroblasts acquire an epithelioid shape and a circular pattern of actin bundles. Pletjushkina OJ, Ivanova OJ, Kaverina IN, Vasiliev JM (1994) Exp Cell Res 212: 201-8 The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z (1996) Exp Cell Res 225: 328-37 Quantification of cell size using temporal diffusion spectroscopy. Jiang X, Li H, Xie J, Zhao P, Gore JC, Xu J (2016) Magn Reson Med 75: 1076-85 Infraorbital nerve transection and whisker follicle removal in adult rats affect microglia and astrocytes in the trigeminal brainstem. A study with lipocortin1- and S100beta-immunohistochemistry. Melzer P, Zhang MZ, McKanna JA (1997) Neuroscience 80: 459-72 Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation. Virostko J, Radhika A, Poffenberger G, Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers AC (2010) Mol Imaging Biol 12: 42-53 Cell cycle-dependent transduction of cell-permeant Cre recombinase proteins. Jo D, Lin Q, Nashabi A, Mays DJ, Unutmaz D, Pietenpol JA, Ruley HE (2003) J Cell Biochem 89: 674-87
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.