Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages. Mueller PA, Zhu L, Tavori H, Huynh K, Giunzioni I, Stafford JM, Linton MF, Fazio S (2018) Circulation 138: 1850-1863 Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Yancey PG, Ding Y, Fan D, Blakemore JL, Zhang Y, Ding L, Zhang J, Linton MF, Fazio S (2011) Circulation 124: 454-64 Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor. Linton MF, Hasty AH, Babaev VR, Fazio S (1998) J Clin Invest 101: 1726-36 Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Overton CD, Yancey PG, Major AS, Linton MF, Fazio S (2007) Circ Res 100: 670-7 Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H (2019) Circ Res 124: e6-e19 Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein. Zhang G, Cai X, López-Guisa JM, Collins SJ, Eddy AA (2004) J Am Soc Nephrol 15: 2090-102 Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition. Zhu L, Giunzioni I, Tavori H, Covarrubias R, Ding L, Zhang Y, Ormseth M, Major AS, Stafford JM, Linton MF, Fazio S (2016) Arterioscler Thromb Vasc Biol 36: 1483-95 Unique pathway for cholesterol uptake in fat cells. Fazio S, Linton MF (2004) Arterioscler Thromb Vasc Biol 24: 1538-9 Macrophage LRP-1 controls plaque cellularity by regulating efferocytosis and Akt activation. Yancey PG, Blakemore J, Ding L, Fan D, Overton CD, Zhang Y, Linton MF, Fazio S (2010) Arterioscler Thromb Vasc Biol 30: 787-95 Serine proteases, inhibitors and receptors in renal fibrosis. Eddy AA (2009) Thromb Haemost 101: 656-64 Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies. Smith CE, Ngwa J, Tanaka T, Qi Q, Wojczynski MK, Lemaitre RN, Anderson JS, Manichaikul A, Mikkilä V, van Rooij FJ, Ye Z, Bandinelli S, Frazier-Wood AC, Houston DK, Hu F, Langenberg C, McKeown NM, Mozaffarian D, North KE, Viikari J, Zillikens MC, Djoussé L, Hofman A, Kähönen M, Kabagambe EK, Loos RJ, Saylor GB, Forouhi NG, Liu Y, Mukamal KJ, Chen YD, Tsai MY, Uitterlinden AG, Raitakari O, van Duijn CM, Arnett DK, Borecki IB, Cupples LA, Ferrucci L, Kritchevsky SB, Lehtimäki T, Qi L, Rotter JI, Siscovick DS, Wareham NJ, Witteman JC, Ordovás JM, Nettleton JA (2013) Int J Obes (Lond) 37: 1211-20 The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles. Cabello-Verrugio C, Santander C, Cofré C, Acuña MJ, Melo F, Brandan E (2012) J Biol Chem 287: 6773-87 Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2). Kurokawa S, Hill KE, McDonald WH, Burk RF (2012) J Biol Chem 287: 28717-26 Epidermal growth factor and platelet-derived growth factor-BB induce a stable increase in the activity of low density lipoprotein receptor-related protein in vascular smooth muscle cells by altering receptor distribution and recycling. Weaver AM, McCabe M, Kim I, Allietta MM, Gonias SL (1996) J Biol Chem 271: 24894-900 Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin. Weaver AM, Hussaini IM, Mazar A, Henkin J, Gonias SL (1997) J Biol Chem 272: 14372-9 Isoform-specific binding of selenoprotein P to the β-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. Kurokawa S, Bellinger FP, Hill KE, Burk RF, Berry MJ (2014) J Biol Chem 289: 9195-207 The association between LRP-1 variants and chylomicron uptake after a high fat meal. Frazier-Wood AC, Kabagambe EK, Wojczynski MK, Borecki IB, Tiwari HK, Smith CE, Ordovas JM, Arnett DK (2013) Nutr Metab Cardiovasc Dis 23: 1154-8 Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. Covarrubias R, Wilhelm AJ, Major AS (2014) PLoS One 9: e102236 Preliminary evidence for an association between LRP-1 genotype and body mass index in humans. Frazier-Wood AC, Kabagambe EK, Borecki IB, Tiwari HK, Ordovas JM, Arnett DK (2012) PLoS One 7: e30732
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.