The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (2007) Nature 450: 566-9 Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y (2006) J Exp Med 203: 2603-11 Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease. Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L, Vossenkämper A, Ahmad N, Snoek SA, Vermeire S, Rutgeerts P, Jordan RE, MacDonald TT (2015) Gastroenterology 149: 1564-1574.e3 Epidermal growth factor receptor inhibits colitis-associated cancer in mice. Dubé PE, Yan F, Punit S, Girish N, McElroy SJ, Washington MK, Polk DB (2012) J Clin Invest 122: 2780-92 Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L (2008) Proc Natl Acad Sci U S A 105: 17931-6 Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ (2000) Cancer Res 60: 4864-8 Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT (2019) Oncogene 38: 1067-1079 Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner. Gowrikumar S, Ahmad R, Uppada SB, Washington MK, Shi C, Singh AB, Dhawan P (2019) Oncogene 38: 5321-5337 Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB (2011) Oncogene 30: 3234-47 The role of chemokines in intestinal inflammation and cancer. Wang D, Dubois RN, Richmond A (2009) Curr Opin Pharmacol 9: 688-96 Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT (2000) Free Radic Biol Med 29: 881-8 Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of adenomas of the GI tract. Zhang H, Morgan D, Cecil G, Burkholder A, Ramocki N, Scull B, Lund PK (2008) Gastrointest Endosc 68: 520-7 Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Vanderpool C, Yan F, Polk DB (2008) Inflamm Bowel Dis 14: 1585-96 Calcaneal ultrasound bone densitometry is not a useful tool to screen patients with inflammatory bowel disease at high risk for metabolic bone disease. Schwartz DA, Connolley CD, Koyama T, Wise PE, Herline AJ (2005) Inflamm Bowel Dis 11: 749-54 Nitric oxide in inflammatory bowel disease. Cross RK, Wilson KT (2003) Inflamm Bowel Dis 9: 179-89 The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ (2012) Inflamm Bowel Dis 18: 112-9 Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease. Achkar JP, Stevens T, Easley K, Brzezinski A, Seidner D, Lashner B (2004) Inflamm Bowel Dis 10: 339-45 Impact of capsule endoscopy on management of inflammatory bowel disease: a single tertiary care center experience. Long MD, Barnes E, Isaacs K, Morgan D, Herfarth HH (2011) Inflamm Bowel Dis 17: 1855-62 The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KT (2011) J Biol Chem 286: 3839-50 Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. Bernard JK, McCann SP, Bhardwaj V, Washington MK, Frey MR (2012) J Biol Chem 287: 39850-8 Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci. Hulur I, Gamazon ER, Skol AD, Xicola RM, Llor X, Onel K, Ellis NA, Kupfer SS (2015) BMC Genomics 16: 138 Probiotics: progress toward novel therapies for intestinal diseases. Yan F, Polk DB (2010) Curr Opin Gastroenterol 26: 95-101 Nutrition in inflammatory bowel disease. Razack R, Seidner DL (2007) Curr Opin Gastroenterol 23: 400-5 Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B (2012) Lab Invest 92: 1749-59 Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE (2017) PLoS One 12: e0179710 Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB (2012) Am J Physiol Gastrointest Liver Physiol 302: G504-14 Use of old and new oral 5-aminosalicylic acid formulations in inflammatory bowel disease. Brzezinski A, Rankin GB, Seidner DL, Lashner BA (1995) Cleve Clin J Med 62: 317-23 Activation and perceived expectancies: correlations with health outcomes among veterans with inflammatory bowel disease. Munson GW, Wallston KA, Dittus RS, Speroff T, Roumie CL (2009) J Gen Intern Med 24: 809-15 TL and CD8αα: Enigmatic partners in mucosal immunity. Olivares-Villagómez D, Van Kaer L (2010) Immunol Lett 134: 1-6 Colonic nitrite and immunoglobulin G concentrations in dogs with inflammatory bowel disease. Gunawardana SC, Jergens AE, Ahrens FA, Niyo Y (1997) J Am Vet Med Assoc 211: 318-21
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