Keyword Connections

•  Albert Reynolds
•  Anna Means
•  Barbara Fingleton

•  Christopher Williams
•  Ethan Lee
•  Natasha Deane

•  Robert Beauchamp

Resources

• No matching connections

Communities

• Beauchamp Laboratory
• Epithelial Biology Center
• Goldenring Lab

Publications

• Proteogenomic characterization of human colon and rectal cancer.
  Zhang B, Wang J, Wang X, Zhu J, Liu Q, Shi Z, Chambers MC, Zimmerman LJ, Shaddox KF, Kim S, Davies SR, Wang S, Wang P, Kinsinger CR, Rivers RC, Rodriguez H, Townsend RR, Ellis MJ, Carr SA, Tabb DL, Coffey RJ, Slebos RJ, Liebler DC, NCI CPTAC
  (2014) Nature 513: 382-7
• Cloning and variation of ground state intestinal stem cells.
  Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W
  (2015) Nature 522: 173-8
• Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
  Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA
  (2010) Nat Genet 42: 77-82
• The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.
  Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ
  (2012) Cell 149: 146-58
• Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
  Byndloss MX, Olsan EE, Rivera-Chávez F, Tiffany CR, Cevallos SA, Lokken KL, Torres TP, Byndloss AJ, Faber F, Gao Y, Litvak Y, Lopez CA, Xu G, Napoli E, Giulivi C, Tsolis RM, Revzin A, Lebrilla CB, Bäumler AJ
  (2017) Science 357: 570-575
• Colonocyte metabolism shapes the gut microbiota.
  Litvak Y, Byndloss MX, Bäumler AJ
  (2018) Science 362:
• Virulence factors enhance Citrobacter rodentium expansion through aerobic respiration.
  Lopez CA, Miller BM, Rivera-Chávez F, Velazquez EM, Byndloss MX, Chávez-Arroyo A, Lokken KL, Tsolis RM, Winter SE, Bäumler AJ
  (2016) Science 353: 1249-53
• Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.
  Dejea CM, Fathi P, Craig JM, Boleij A, Taddese R, Geis AL, Wu X, DeStefano Shields CE, Hechenbleikner EM, Huso DL, Anders RA, Giardiello FM, Wick EC, Wang H, Wu S, Pardoll DM, Housseau F, Sears CL
  (2018) Science 359: 592-597
• Aspirin-like molecules that covalently inactivate cyclooxygenase-2.
  Kalgutkar AS, Crews BC, Rowlinson SW, Garner C, Seibert K, Marnett LJ
  (1998) Science 280: 1268-70
• The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
  Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H
  (2009) Nat Immunol 10: 769-77
• BRAF: a driver of the serrated pathway in colon cancer.
  Rustgi AK
  (2013) Cancer Cell 24: 1-2
• Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
  Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M
  (2013) Cancer Cell 23: 634-46
• Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.
  Zackular JP, Moore JL, Jordan AT, Juttukonda LJ, Noto MJ, Nicholson MR, Crews JD, Semler MW, Zhang Y, Ware LB, Washington MK, Chazin WJ, Caprioli RM, Skaar EP
  (2016) Nat Med 22: 1330-1334
• The germ-organ theory of non-communicable diseases.
  Byndloss MX, Bäumler AJ
  (2018) Nat Rev Microbiol 16: 103-110
• COX-2: a target for colon cancer prevention.
  Marnett LJ, DuBois RN
  (2002) Annu Rev Pharmacol Toxicol 42: 55-80
• MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
  Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE
  (2018) Mol Cell 70: 936-948.e7
• The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
  Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD
  (2014) Cell Metab 20: 1018-29
• JAM-A regulates permeability and inflammation in the intestine in vivo.
  Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, Dermody TS, Nusrat A, Parkos CA
  (2007) J Exp Med 204: 3067-76
• Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
  An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L
  (2007) J Exp Med 204: 1417-29
• Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
  Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E
  (2010) Nat Chem Biol 6: 829-36
• SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity.
  Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ, Shroyer NF
  (2013) Gastroenterology 144: 1012-1023.e6
• Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice.
  Shattuck-Brandt RL, Varilek GW, Radhika A, Yang F, Washington MK, DuBois RN
  (2000) Gastroenterology 118: 337-45
• Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8(+) T Cells in Mice With Colitis.
  Punit S, Dubé PE, Liu CY, Girish N, Washington MK, Polk DB
  (2015) Gastroenterology 149: 993-1005.e2
• Immunolocalization of alpha-integrin subunits and extracellular matrix components during human colonic organogenesis.
  Dieckgraefe BK, Santoro SA, Alpers DH
  (1996) Gastroenterology 110: 58-71
• The role of PPARgamma in colon cancer: is it as simple as APC?
  Peek RM
  (2003) Gastroenterology 125: 619-21
• Accuracy of capsule colonoscopy in detecting colorectal polyps in a screening population.
  Rex DK, Adler SN, Aisenberg J, Burch WC, Carretero C, Chowers Y, Fein SA, Fern SE, Fernandez-Urien Sainz I, Fich A, Gal E, Horlander JC, Isaacs KL, Kariv R, Lahat A, Leung WK, Malik PR, Morgan D, Papageorgiou N, Romeo DP, Shah SS, Waterman M
  (2015) Gastroenterology 148: 948-957.e2
• Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression.
  Fujimoto K, Beauchamp RD, Whitehead RH
  (2002) Gastroenterology 123: 1941-8
• Identification and Characterization of Unique Neutralizing Antibodies to Mouse EGF Receptor.
  Jae Huh W, Niitsu H, Carney B, McKinley ET, Houghton JL, Coffey RJ
  (2020) Gastroenterology 158: 1500-1502
• No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases.
  Mahmoud R, Shah SC, Ten Hove JR, Torres J, Mooiweer E, Castaneda D, Glass J, Elman J, Kumar A, Axelrad J, Ullman T, Colombel JF, Oldenburg B, Itzkowitz SH, Dutch Initiative on Crohn and Colitis
  (2019) Gastroenterology 156: 1333-1344.e3
• Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB.
  Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB
  (2008) Gastroenterology 135: 539-51
• Effects of Cancer Stage and Treatment Differences on Racial Disparities in Survival From Colon Cancer: A United States Population-Based Study.
  Lai Y, Wang C, Civan JM, Palazzo JP, Ye Z, Hyslop T, Lin J, Myers RE, Li B, Jiang B, Sama A, Xing J, Yang H
  (2016) Gastroenterology 150: 1135-1146
• Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
  Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ
  (2008) Gastroenterology 134: 2036-48, 2048.e1-3
• Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.
  Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA
  (2017) Gastroenterology 152: 1345-1357.e7
• Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells.
  Singh AB, Sharma A, Smith JJ, Krishnan M, Chen X, Eschrich S, Washington MK, Yeatman TJ, Beauchamp RD, Dhawan P
  (2011) Gastroenterology 141: 2140-53
• Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.
  Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L, Vossenkämper A, Ahmad N, Snoek SA, Vermeire S, Rutgeerts P, Jordan RE, MacDonald TT
  (2015) Gastroenterology 149: 1564-1574.e3
• Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines.
  Adachi Y, Lee CT, Coffee K, Yamagata N, Ohm JE, Park KH, Dikov MM, Nadaf SR, Arteaga CL, Carbone DP
  (2002) Gastroenterology 123: 1191-204
• It's about time: clock genes unveiled in the gut.
  Scheving LA, Russell WE
  (2007) Gastroenterology 133: 1373-6