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•  Danielle Dean

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Publications

• Cell-programmed nutrient partitioning in the tumour microenvironment.
  Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, Muir A, Lewis CA, Hongo RA, Young KL, Brown RE, Todd VM, Huffstater T, Abraham A, O'Neil RT, Wilson MH, Xin F, Tantawy MN, Merryman WD, Johnson RW, Williams CS, Mason EF, Mason FM, Beckermann KE, Vander Heiden MG, Manning HC, Rathmell JC, Rathmell WK
  (2021) Nature 593: 282-288
• Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
  Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR
  (1994) Science 265: 1405-12
• Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models.
  Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, Sharick JT, Skala MC, Smith JA, Berlin J, Washington MK, Nickels ML, Manning HC
  (2018) Nat Med 24: 194-202
• Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models.
  Day M, Wang Z, Ding J, An X, Ingham CA, Shering AF, Wokosin D, Ilijic E, Sun Z, Sampson AR, Mugnaini E, Deutch AY, Sesack SR, Arbuthnott GW, Surmeier DJ
  (2006) Nat Neurosci 9: 251-9
• Metabolite profiling identifies pathways associated with metabolic risk in humans.
  Cheng S, Rhee EP, Larson MG, Lewis GD, McCabe EL, Shen D, Palma MJ, Roberts LD, Dejam A, Souza AL, Deik AA, Magnusson M, Fox CS, O'Donnell CJ, Vasan RS, Melander O, Clish CB, Gerszten RE, Wang TJ
  (2012) Circulation 125: 2222-31
• In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
  Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O
  (2013) Cell Metab 17: 372-85
• Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
  Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV
  (2012) Cell Metab 15: 110-21
• Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.
  Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC
  (2017) Cell Metab 25: 1362-1373.e5
• Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response.
  Desimone MC, Rathmell WK, Threadgill DW
  (2013) J Natl Cancer Inst 105: 1355-64
• Effect of chemically induced diabetes mellitus on glutamine transport in rat intestine.
  Van Voorhis K, Said HM, Abumrad N, Ghishan FK
  (1990) Gastroenterology 98: 862-6
• Decreased ureagenesis from alanine, but not from ammonia and glutamine, in the perfused rat liver after partial hepatectomy.
  Moriyama M, Makiyama I, Shiota M, Uesugi K, Kannan Y, Ohta M, Kimura K, Sugano T
  (1996) Hepatology 23: 1584-90
• The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer.
  Youngblood VM, Kim LC, Edwards DN, Hwang Y, Santapuram PR, Stirdivant SM, Lu P, Ye F, Brantley-Sieders DM, Chen J
  (2016) Cancer Res 76: 1825-36
• Inhibition of pentagastrin-stimulated up-regulation of gastrin receptors and growth of mouse colon tumor in vivo by proglumide, a gastrin receptor antagonist.
  Singh P, Le S, Beauchamp RD, Townsend CM, Thompson JC
  (1987) Cancer Res 47: 5000-4
• Metabolic flux rewiring in mammalian cell cultures.
  Young JD
  (2013) Curr Opin Biotechnol 24: 1108-15
• SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
  Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP
  (2013) Clin Cancer Res 19: 560-70
• Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls.
  Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, Guzman R, Cai T, Gupta N, Gainer V, Schur P, Cui J, Denny JC, Szolovits P, Churchill S, Kohane I, Karlson EW, Plenge RM
  (2013) Arthritis Rheum 65: 571-81
• xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.
  Ji X, Qian J, Rahman SMJ, Siska PJ, Zou Y, Harris BK, Hoeksema MD, Trenary IA, Heidi C, Eisenberg R, Rathmell JC, Young JD, Massion PP
  (2018) Oncogene 37: 5007-5019
• Glutamine transport by human intestinal basolateral membrane vesicle.
  Ghishan FK, Arab N, Bulus N, Said H, Pietsch J, Abumrad N
  (1990) Am J Clin Nutr 51: 612-6
• Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice.
  Beauchamp RD, Townsend CM, Singh P, Glass EJ, Thompson JC
  (1985) Ann Surg 202: 303-9
• Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.
  Hassanein M, Qian J, Hoeksema MD, Wang J, Jacobovitz M, Ji X, Harris FT, Harris BK, Boyd KL, Chen H, Eisenberg R, Massion PP
  (2015) Int J Cancer 137: 1587-97
• Neuronal signaling and the regulation of bone remodeling.
  Elefteriou F
  (2005) Cell Mol Life Sci 62: 2339-49
• Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
  Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC
  (2021) J Immunol 206: 1127-1139
• Gamma-glutamylmethylamide. A new intermediate in the metabolism of methylamine.
  Kung HF, Wagner C
  (1969) J Biol Chem 244: 4136-40
• The role of high molecular weight kininogen and prothrombin as cofactors in the binding of factor XI A3 domain to the platelet surface.
  Ho DH, Badellino K, Baglia FA, Sun MF, Zhao MM, Gailani D, Walsh PN
  (2000) J Biol Chem 275: 25139-45
• Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain.
  Goodman OB, Krupnick JG, Gurevich VV, Benovic JL, Keen JH
  (1997) J Biol Chem 272: 15017-22
• Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation.
  Landino LM, Crews BC, Gierse JK, Hauser SD, Marnett LJ
  (1997) J Biol Chem 272: 21565-74
• Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis.
  Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G
  (2009) J Biol Chem 284: 33425-36
• Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux.
  Egnatchik RA, Leamy AK, Sacco SA, Cheah YE, Shiota M, Young JD
  (2019) J Biol Chem 294: 3081-3090
• The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo.
  Ryan KJ, Zhou Y, Wente SR
  (2007) Mol Biol Cell 18: 886-98
• Growth hormone, glutamine, and modified diet for intestinal adaptation.
  Matarese LE, Seidner DL, Steiger E
  (2004) J Am Diet Assoc 104: 1265-72
• Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.
  Albertolle ME, Song HD, Wilkey CJ, Segrest JP, Guengerich FP
  (2019) Chem Res Toxicol 32: 484-492
• Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation.
  Anderson PM, Ramsay NK, Shu XO, Rydholm N, Rogosheske J, Nicklow R, Weisdorf DJ, Skubitz KM
  (1998) Bone Marrow Transplant 22: 339-44
• Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis.
  Williams D, Fingleton B
  (2019) Clin Exp Metastasis 36: 211-224
• Backbone dynamics of calcium-loaded calbindin D9k studied by two-dimensional proton-detected 15N NMR spectroscopy.
  Kördel J, Skelton NJ, Akke M, Palmer AG, Chazin WJ
  (1992) Biochemistry 31: 4856-66
• A practical method for uniform isotopic labeling of recombinant proteins in mammalian cells.
  Hansen AP, Petros AM, Mazar AP, Pederson TM, Rueter A, Fesik SW
  (1992) Biochemistry 31: 12713-8
• Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
  Guengerich FP, Hanna IH, Martin MV, Gillam EM
  (2003) Biochemistry 42: 1245-53
• Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation.
  Ko TC, Beauchamp RD, Townsend CM, Thompson JC
  (1993) Surgery 114: 147-53; discussion 153-4
• Proglumide inhibits cholecystokinin and meal-stimulated pancreatic secretion and release of pancreatic polypeptide.
  Beauchamp RD, Gomez G, Nealon WH, Townsend CM, Greeley GH, Thompson JC
  (1990) Surgery 108: 553-8
• The capacity of the malate-aspartate shuttle differs between periportal and perivenous hepatocytes from rats.
  Shiota M, Hiramatsu M, Fujimoto Y, Moriyama M, Kimura K, Ohta M, Sugano T
  (1994) Arch Biochem Biophys 308: 349-56
• Physiologic importance of glutamine.
  Bulus N, Cersosimo E, Ghishan F, Abumrad NN
  (1989) Metabolism 38: 1-5