EGF receptor mutations in lung cancer: from humans to mice and maybe back to humans. Arteaga CL (2006) Cancer Cell 9: 421-3 Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia. Moslehi JJ, Deininger M (2015) J Clin Oncol 33: 4210-8 TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer. Bhola NE, Balko JM, Dugger TC, Kuba MG, Sánchez V, Sanders M, Stanford J, Cook RS, Arteaga CL (2013) J Clin Invest 123: 1348-58 BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK (2016) Circ Res 119: 434-49 Focal energy deprivation underlies arrhythmia susceptibility in mice with calcium-sensitized myofilaments. Huke S, Venkataraman R, Faggioni M, Bennuri S, Hwang HS, Baudenbacher F, Knollmann BC (2013) Circ Res 112: 1334-44 Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions. Wang F, DeMuro NE, Elmquist CE, Stover JS, Rizzo CJ, Stone MP (2006) J Am Chem Soc 128: 10085-95 Site-specific synthesis and properties of oligonucleotides containing C8-deoxyguanosine adducts of the dietary mutagen IQ. Elmquist CE, Stover JS, Wang Z, Rizzo CJ (2004) J Am Chem Soc 126: 11189-201 An Acquired Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Hanker AB, Brewer MR, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, Lovly CM, Meiler J, Arteaga CL (2017) Cancer Discov 7: 575-585 Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer. Formisano L, Lu Y, Servetto A, Hanker AB, Jansen VM, Bauer JA, Sudhan DR, Guerrero-Zotano AL, Croessmann S, Guo Y, Ericsson PG, Lee KM, Nixon MJ, Schwarz LJ, Sanders ME, Dugger TC, Cruz MR, Behdad A, Cristofanilli M, Bardia A, O'Shaughnessy J, Nagy RJ, Lanman RB, Solovieff N, He W, Miller M, Su F, Shyr Y, Mayer IA, Balko JM, Arteaga CL (2019) Nat Commun 10: 1373 Pitavastatin enhances antiviral efficacy of standard pegylated interferon plus ribavirin in patients with chronic hepatitis C: a prospective randomized pilot study. Shimada M, Yoshida S, Masuzaki R, Schuppan D (2012) J Hepatol 56: 299-300 The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Petrie KA, Bubser M, Casey CD, Davis MD, Roth BL, Deutch AY (2004) Neuropsychopharmacology 29: 1878-88 Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations. Dean B, Hopper S, Conn PJ, Scarr E (2016) Neuropsychopharmacology 41: 1620-8 DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cells. Bose A, Pande P, Jasti VP, Millsap AD, Hawkins EK, Rizzo CJ, Basu AK (2015) Nucleic Acids Res 43: 8340-51 A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC (2014) Clin Cancer Res 20: 2126-35 Inhibition of BMP signaling suppresses metastasis in mammary cancer. Owens P, Pickup MW, Novitskiy SV, Giltnane JM, Gorska AE, Hopkins CR, Hong CC, Moses HL (2015) Oncogene 34: 2437-49 Neurotensin activates GABAergic interneurons in the prefrontal cortex. Petrie KA, Schmidt D, Bubser M, Fadel J, Carraway RE, Deutch AY (2005) J Neurosci 25: 1629-36 Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. Felts AS, Rodriguez AL, Smith KA, Engers JL, Morrison RD, Byers FW, Blobaum AL, Locuson CW, Chang S, Venable DF, Niswender CM, Daniels JS, Conn PJ, Lindsley CW, Emmitte KA (2015) J Med Chem 58: 9027-40 In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. Hao J, Ho JN, Lewis JA, Karim KA, Daniels RN, Gentry PR, Hopkins CR, Lindsley CW, Hong CC (2010) ACS Chem Biol 5: 245-53 EGFR mutant lung cancer. Gong Y, Pao W (2012) Curr Top Microbiol Immunol 355: 59-81 Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267. Dooley KE, Park JG, Swindells S, Allen R, Haas DW, Cramer Y, Aweeka F, Wiggins I, Gupta A, Lizak P, Qasba S, van Heeswijk R, Flexner C, ACTG 5267 Study Team (2012) J Acquir Immune Defic Syndr 59: 455-62 Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. Choi JY, Stover JS, Angel KC, Chowdhury G, Rizzo CJ, Guengerich FP (2006) J Biol Chem 281: 25297-306 Fluoroquinolone susceptibility in Mycobacterium tuberculosis after pre-diagnosis exposure to older- versus newer-generation fluoroquinolones. van der Heijden YF, Maruri F, Blackman A, Mitchel E, Bian A, Shintani AK, Eden S, Warkentin JV, Sterling TR (2013) Int J Antimicrob Agents 42: 232-7 Pro32Pro33 mutations in the integrin β3 PSI domain result in αIIbβ3 priming and enhanced adhesion: reversal of the hypercoagulability phenotype by the Src inhibitor SKI-606. Oliver KH, Jessen T, Crawford EL, Chung CY, Sutcliffe JS, Carneiro AM (2014) Mol Pharmacol 85: 921-31 An improved procedure for the synthesis of glycine and taurine conjugates of bile acids. Tserng KY, Hachey DL, Klein PD (1977) J Lipid Res 18: 404-7 Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. Jacobson DA, Mendez F, Thompson M, Torres J, Cochet O, Philipson LH (2010) J Physiol 588: 3525-37 Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Hover LD, Young CD, Bhola NE, Wilson AJ, Khabele D, Hong CC, Moses HL, Owens P (2015) Cancer Lett 368: 79-87 Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2. Turesky RJ, Constable A, Fay LB, Guengerich FP (1999) Cancer Lett 143: 109-12 Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Sheffler DJ, Conn PJ (2008) Neuropharmacology 55: 419-27 Urinary cysteinyl leukotriene E4 significantly increases during pain in children and adults with sickle cell disease. Field JJ, Strunk RC, Knight-Perry JE, Blinder MA, Townsend RR, DeBaun MR (2009) Am J Hematol 84: 231-3 Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase. Aryal P, Yoshikawa K, Terashita T, Guengerich FP, Shimada T, Oda Y (1999) Mutat Res 442: 113-20 Plasmid-mediated expression of the UmuDC mutagenesis proteins in an Escherichia coli strain engineered for human cytochrome P450 1A2-catalyzed activation of aromatic amines. Josephy PD, Evans DH, Williamson V, Henry T, Guengerich FP (1999) Mutat Res 429: 199-208 Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis. Ribeiro LR, Loures FV, de Araújo EF, Feriotti C, Costa TA, Serezani CH, Jancar S, Calich VL (2015) Mediators Inflamm 2015: 852574 DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB (2012) ACS Chem Neurosci 3: 482-91 Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer. Li B, Lu W, Yang Q, Yu X, Matusik RJ, Chen Z (2014) Prostate 74: 421-32 Optical metabolic imaging of treatment response in human head and neck squamous cell carcinoma. Shah AT, Demory Beckler M, Walsh AJ, Jones WP, Pohlmann PR, Skala MC (2014) PLoS One 9: e90746 Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay. Aryal P, Terashita T, Guengerich FP, Shimada T, Oda Y (2000) Environ Mol Mutagen 36: 121-6 The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ (2010) Chem Res Toxicol 23: 1076-88 Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Langouët S, Furge LL, Kerriguy N, Nakamura K, Guillouzo A, Guengerich FP (2000) Chem Res Toxicol 13: 245-52 Conformational differences of the C8-deoxyguanosine adduct of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) within the NarI recognition sequence. Elmquist CE, Wang F, Stover JS, Stone MP, Rizzo CJ (2007) Chem Res Toxicol 20: 445-54 Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Stover JS, Chowdhury G, Zang H, Guengerich FP, Rizzo CJ (2006) Chem Res Toxicol 19: 1506-17
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.