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- Cancer-drug discovery and cardiovascular surveillance.
Groarke JD, Cheng S, Moslehi J
(2013) N Engl J Med 369: 1779-81 - Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations.
Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J
(2012) N Engl J Med 367: 1694-703 - Targeting Plasmodium PI(4)K to eliminate malaria.
McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA
(2013) Nature 504: 248-253 - Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction.
Sy JC, Seshadri G, Yang SC, Brown M, Oh T, Dikalov S, Murthy N, Davis ME
(2008) Nat Mater 7: 863-8 - Tyrosine Kinase Inhibitor-Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia.
Moslehi JJ, Deininger M
(2015) J Clin Oncol 33: 4210-8 - Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein.
Communal C, Singh K, Sawyer DB, Colucci WS
(1999) Circulation 100: 2210-2 - Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride.
Cheng HF, Wang JL, Zhang MZ, McKanna JA, Harris RC
(2000) J Clin Invest 106: 681-8 - Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, Fogo A, Utsunomiya H, Inagami T, Ichikawa I
(1998) J Clin Invest 101: 755-60 - Viral acute lower respiratory infections impair CD8+ T cells through PD-1.
Erickson JJ, Gilchuk P, Hastings AK, Tollefson SJ, Johnson M, Downing MB, Boyd KL, Johnson JE, Kim AS, Joyce S, Williams JV
(2012) J Clin Invest 122: 2967-82 - Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.
FitzGerald GA, Brash AR, Oates JA, Pedersen AK
(1983) J Clin Invest 72: 1336-43 - Retinal angiogenesis suppression through small molecule activation of p53.
Chavala SH, Kim Y, Tudisco L, Cicatiello V, Milde T, Kerur N, Claros N, Yanni S, Guaiquil VH, Hauswirth WW, Penn JS, Rafii S, De Falco S, Lee TC, Ambati J
(2013) J Clin Invest 123: 4170-81 - The effects of RO-22-4679, a thromboxane synthetase inhibitor, on ventricular fibrillation induced by coronary artery occlusion in conscious dogs.
Huddleston CB, Lupinetti FM, Laws KH, Collins JC, Clanton JA, Hawiger JJ, Oates JA, Hammon JW
(1983) Circ Res 52: 608-13 - Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors.
Shi H, Moriceau G, Kong X, Koya RC, Nazarian R, Pupo GM, Bacchiocchi A, Dahlman KB, Chmielowski B, Sosman JA, Halaban R, Kefford RF, Long GV, Ribas A, Lo RS
(2012) Cancer Discov 2: 414-24 - Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy.
Shi H, Hugo W, Kong X, Hong A, Koya RC, Moriceau G, Chodon T, Guo R, Johnson DB, Dahlman KB, Kelley MC, Kefford RF, Chmielowski B, Glaspy JA, Sosman JA, van Baren N, Long GV, Ribas A, Lo RS
(2014) Cancer Discov 4: 80-93 - Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway.
Shi J, Guan J, Jiang B, Brenner DA, Del Monte F, Ward JE, Connors LH, Sawyer DB, Semigran MJ, Macgillivray TE, Seldin DC, Falk R, Liao R
(2010) Proc Natl Acad Sci U S A 107: 4188-93 - Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors.
Podust LM, Poulos TL, Waterman MR
(2001) Proc Natl Acad Sci U S A 98: 3068-73 - Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.
Tan CM, Wilson MH, MacMillan LB, Kobilka BK, Limbird LE
(2002) Proc Natl Acad Sci U S A 99: 12471-6 - Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib.
Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, Ozawa K, Shentu W, Brown E, Shirai T, McCarty OJ, Ruggeri Z, Moslehi J, Chen J, Druker BJ, López JA, Lindner JR
(2019) Blood 133: 1597-1606 - Muscarinic M receptors modulate ethanol seeking in rats.
Berizzi AE, Perry CJ, Shackleford DM, Lindsley CW, Jones CK, Chen NA, Sexton PM, Christopoulos A, Langmead CJ, Lawrence AJ
(2018) Neuropsychopharmacology 43: 1510-1517 - Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters.
Zhu CB, Lindler KM, Owens AW, Daws LC, Blakely RD, Hewlett WA
(2010) Neuropsychopharmacology 35: 2510-20 - Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.
Shimada T, Guengerich FP
(1991) Cancer Res 51: 5284-91 - Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells.
Vilgelm AE, Pawlikowski JS, Liu Y, Hawkins OE, Davis TA, Smith J, Weller KP, Horton LW, McClain CM, Ayers GD, Turner DC, Essaka DC, Stewart CF, Sosman JA, Kelley MC, Ecsedy JA, Johnston JN, Richmond A
(2015) Cancer Res 75: 181-93 - A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.
Fox EM, Miller TW, Balko JM, Kuba MG, Sánchez V, Smith RA, Liu S, González-Angulo AM, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL
(2011) Cancer Res 71: 6773-84 - Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis.
Brown NJ
(2013) Nat Rev Nephrol 9: 459-69 - Bradykinin causes selective efferent arteriolar dilation during angiotensin I converting enzyme inhibition.
Kon V, Fogo A, Ichikawa I
(1993) Kidney Int 44: 545-50 - The angiotensin type II receptor tonically inhibits angiotensin- converting enzyme in AT2 null mutant mice.
Hunley TE, Tamura M, Stoneking BJ, Nishimura H, Ichiki T, Inagami T, Kon V
(2000) Kidney Int 57: 570-7 - Modulation of plasminogen activator inhibitor-1 in vivo: a new mechanism for the anti-fibrotic effect of renin-angiotensin inhibition.
Oikawa T, Freeman M, Lo W, Vaughan DE, Fogo A
(1997) Kidney Int 51: 164-72 - Blood pressure-independent effect of angiotensin inhibition on vascular lesions of chronic renal failure.
Kakinuma Y, Kawamura T, Bills T, Yoshioka T, Ichikawa I, Fogo A
(1992) Kidney Int 42: 46-55 - Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.
Pitts TM, Tan AC, Kulikowski GN, Tentler JJ, Brown AM, Flanigan SA, Leong S, Coldren CD, Hirsch FR, Varella-Garcia M, Korch C, Eckhardt SG
(2010) Clin Cancer Res 16: 3193-204 - Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacy.
Fingleton B, Menon R, Carter KJ, Overstreet PD, Hachey DL, Matrisian LM, McIntyre JO
(2004) Clin Cancer Res 10: 7865-74 - BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways.
Yang J, Amiri KI, Burke JR, Schmid JA, Richmond A
(2006) Clin Cancer Res 12: 950-60 - 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer.
McKinley ET, Bugaj JE, Zhao P, Guleryuz S, Mantis C, Gokhale PC, Wild R, Manning HC
(2011) Clin Cancer Res 17: 3332-40 - A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.
Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC
(2014) Clin Cancer Res 20: 2126-35 - RAF265 inhibits the growth of advanced human melanoma tumors.
Su Y, Vilgelm AE, Kelley MC, Hawkins OE, Liu Y, Boyd KL, Kantrow S, Splittgerber RC, Short SP, Sobolik T, Zaja-Milatovic S, Dahlman KB, Amiri KI, Jiang A, Lu P, Shyr Y, Stuart DD, Levy S, Sosman JA, Richmond A
(2012) Clin Cancer Res 18: 2184-98 - Hypoxia and Reactive Oxygen Species Homeostasis in Mesenchymal Progenitor Cells Define a Molecular Mechanism for Fracture Nonunion.
Muinos-López E, Ripalda-Cemboráin P, López-Martínez T, González-Gil AB, Lamo-Espinosa JM, Valentí A, Mortlock DP, Valentí JR, Prósper F, Granero-Moltó F
(2016) Stem Cells 34: 2342-53 - Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.
Alarcon-Vargas D, Tansey WP, Ronai Z
(2002) Oncogene 21: 4384-91 - An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Khurana S, Liu Z, Lewis AS, Rosa K, Chetkovich D, Golding NL
(2012) J Neurosci 32: 2814-23 - Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation.
Chang JC, Tomlinson ID, Warnement MR, Ustione A, Carneiro AM, Piston DW, Blakely RD, Rosenthal SJ
(2012) J Neurosci 32: 8919-29 - Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans.
Gandhi SK, Ryder DH, Brown NJ
(1996) Hypertension 28: 961-6 - Effect of the acyl-CoA:cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans.
Hainer JW, Terry JG, Connell JM, Zyruk H, Jenkins RM, Shand DL, Gillies PJ, Livak KJ, Hunt TL, Crouse JR
(1994) Clin Pharmacol Ther 56: 65-74
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