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Connections to DNA Polymerase I are shown below. Double-click or tap a node for more information.
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- Interactions of carcinogen-bound DNA with individual DNA polymerases.
Guengerich FP
(2006) Chem Rev 106: 420-52 - How the ubiquitin-proteasome system controls transcription.
Muratani M, Tansey WP
(2003) Nat Rev Mol Cell Biol 4: 192-201 - Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF
(2012) Nat Genet 44: 1282-5 - Cadmium is a mutagen that acts by inhibiting mismatch repair.
Jin YH, Clark AB, Slebos RJ, Al-Refai H, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA
(2003) Nat Genet 34: 326-9 - DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase.
Paeschke K, Capra JA, Zakian VA
(2011) Cell 145: 678-91 - Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.
Saitoh S, Chabes A, McDonald WH, Thelander L, Yates JR, Russell P
(2002) Cell 109: 563-73 - Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA.
Weil PA, Luse DS, Segall J, Roeder RG
(1979) Cell 18: 469-84 - Ubiquitin and proteasomes in transcription.
Geng F, Wenzel S, Tansey WP
(2012) Annu Rev Biochem 81: 177-201 - Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.
Liu Y, Sethi NS, Hinoue T, Schneider BG, Cherniack AD, Sanchez-Vega F, Seoane JA, Farshidfar F, Bowlby R, Islam M, Kim J, Chatila W, Akbani R, Kanchi RS, Rabkin CS, Willis JE, Wang KK, McCall SJ, Mishra L, Ojesina AI, Bullman S, Pedamallu CS, Lazar AJ, Sakai R, Cancer Genome Atlas Research Network, Thorsson V, Bass AJ, Laird PW
(2018) Cancer Cell 33: 721-735.e8 - The steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural data.
Egli M
(2012) Acc Chem Res 45: 1237-46 - Checkpoint signaling from a single DNA interstrand crosslink.
Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J
(2009) Mol Cell 35: 704-15 - The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.
Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D
(2015) Mol Cell 59: 998-1010 - A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome.
Venters BJ, Pugh BF
(2009) Genome Res 19: 360-71 - Replication of N2,3-ethenoguanine by DNA polymerases.
Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP
(2012) Angew Chem Int Ed Engl 51: 5466-9 - Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.
Eoff RL, McGrath CE, Maddukuri L, Salamanca-Pinzón SG, Marquez VE, Marnett LJ, Guengerich FP, Egli M
(2010) Angew Chem Int Ed Engl 49: 7481-5 - Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling.
Cortez D
(2005) Genes Dev 19: 1007-12 - Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase η and Sulfolobus solfataricus P2 Polymerase IV.
Patra A, Banerjee S, Johnson Salyard TL, Malik CK, Christov PP, Rizzo CJ, Stone MP, Egli M
(2015) J Am Chem Soc 137: 7011-4 - A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota.
Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL
(2012) J Am Chem Soc 134: 10698-705 - Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV.
Banerjee S, Brown KL, Egli M, Stone MP
(2011) J Am Chem Soc 133: 12556-68 - Molecular basis for PrimPol recruitment to replication forks by RPA.
Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ
(2017) Nat Commun 8: 15222 - What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr?
Neeve VC, Samuels DC, Bindoff LA, van den Bosch B, Van Goethem G, Smeets H, Lombès A, Jardel C, Hirano M, Dimauro S, De Vries M, Smeitink J, Smits BW, de Coo IF, Saft C, Klopstock T, Keiling BC, Czermin B, Abicht A, Lochmüller H, Hudson G, Gorman GG, Turnbull DM, Taylor RW, Holinski-Feder E, Chinnery PF, Horvath R
(2012) Brain 135: 3614-26 - Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Brieba LG, Eichman BF, Kokoska RJ, Doublié S, Kunkel TA, Ellenberger T
(2004) EMBO J 23: 3452-61 - Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation.
Andrau JC, Van Oevelen CJ, Van Teeffelen HA, Weil PA, Holstege FC, Timmers HT
(2002) EMBO J 21: 5173-83 - Endogenous DNA damage and mutation.
Marnett LJ, Plastaras JP
(2001) Trends Genet 17: 214-21 - Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II.
Cline SD, Riggins JN, Tornaletti S, Marnett LJ, Hanawalt PC
(2004) Proc Natl Acad Sci U S A 101: 7275-80 - Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo.
Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM
(2015) Nucleic Acids Res 43: 5489-500 - DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cells.
Bose A, Pande P, Jasti VP, Millsap AD, Hawkins EK, Rizzo CJ, Basu AK
(2015) Nucleic Acids Res 43: 8340-51 - Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M1dG.
Cline SD, Lodeiro MF, Marnett LJ, Cameron CE, Arnold JJ
(2010) Nucleic Acids Res 38: 7546-57 - Biochemical and genetic characterization of the dominant positive element driving transcription ofthe yeast TBP-encoding gene, SPT15.
Schroeder SC, Weil PA
(1998) Nucleic Acids Res 26: 4186-95 - Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.
Guilliam TA, Jozwiakowski SK, Ehlinger A, Barnes RP, Rudd SG, Bailey LJ, Skehel JM, Eckert KA, Chazin WJ, Doherty AJ
(2015) Nucleic Acids Res 43: 1056-68 - Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA
(1999) Oncogene 18: 1219-26 - Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.
Liu B, Xue Q, Tang Y, Cao J, Guengerich FP, Zhang H
(2016) Mutat Res Rev Mutat Res 768: 53-67 - TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η.
Wallace HA, Merkle JA, Yu MC, Berg TG, Lee E, Bosco G, Lee LA
(2014) Development 141: 1332-41 - Structural basis for DNA binding by replication initiator Mcm10.
Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF
(2008) Structure 16: 1892-901 - The contribution of UDP-glucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines.
Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, Guengerich FP, Tukey RH
(2001) Carcinogenesis 22: 943-50 - Mechanisms of formation of DNA adducts from ethylene dihalides, vinyl halides, and arylamines.
Guengerich FP
(1994) Drug Metab Rev 26: 47-66 - Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity.
Loffredo JT, Sidney J, Bean AT, Beal DR, Bardet W, Wahl A, Hawkins OE, Piaskowski S, Wilson NA, Hildebrand WH, Watkins DI, Sette A
(2009) J Immunol 182: 7763-75
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