Sirt1 activation protects the mouse renal medulla from oxidative injury. He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM (2010) J Clin Invest 120: 1056-68 Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T (1995) J Clin Invest 96: 2947-54 Dehydration activates an NF-kappaB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells. Hao CM, Yull F, Blackwell T, Kömhoff M, Davis LS, Breyer MD (2000) J Clin Invest 106: 973-82 Ionophores stimulate prostaglandin and thromboxane biosynthesis. Knapp HR, Oelz O, Roberts LJ, Sweetman BJ, Oates JA, Reed PW (1977) Proc Natl Acad Sci U S A 74: 4251-5 1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man. Avison MJ, Rothman DL, Nixon TW, Long WS, Siegel NJ (1991) Proc Natl Acad Sci U S A 88: 6053-7 Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia. Sparrow DB, Boyle SC, Sams RS, Mazuruk B, Zhang L, Moeckel GW, Dunwoodie SL, de Caestecker MP (2009) J Am Soc Nephrol 20: 777-86 Cyclooxygenase-2 in the kidney. Harris RC (2000) J Am Soc Nephrol 11: 2387-94 ddAVP does not stimulate acute changes in levels of medullary trimethylamines in humans. Avison MJ, Van Why SK, Siegel NJ (1993) J Am Soc Nephrol 4: 1379-84 Deletion of ErbB4 accelerates polycystic kidney disease progression in cpk mice. Zeng F, Miyazawa T, Kloepfer LA, Harris RC (2014) Kidney Int 86: 538-47 Angiotensin II: breathtaking in the renal medulla. Haase VH (2011) Kidney Int 79: 269-71 The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy. Miyazaki Y, Tsuchida S, Fogo A, Ichikawa I (1999) Kidney Int 55: 1683-95 Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Schneider A, Zhang Y, Zhang M, Lu WJ, Rao R, Fan X, Redha R, Davis L, Breyer RM, Harris R, Guan Y, Breyer MD (2004) Kidney Int 65: 1205-13 Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells. Raphael KL, Strait KA, Stricklett PK, Miller RL, Nelson RD, Piontek KB, Germino GG, Kohan DE (2009) Kidney Int 75: 626-33 Renal Medullary Interstitial COX-2 (Cyclooxygenase-2) Is Essential in Preventing Salt-Sensitive Hypertension and Maintaining Renal Inner Medulla/Papilla Structural Integrity. Zhang MZ, Wang S, Wang Y, Zhang Y, Ming Hao C, Harris RC (2018) Hypertension 72: 1172-1179 Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. Yao B, Harris RC, Zhang MZ (2009) Hypertension 54: 1077-83 Increased dietary sodium induces COX2 expression by activating NFκB in renal medullary interstitial cells. He W, Zhang M, Zhao M, Davis LS, Blackwell TS, Yull F, Breyer MD, Hao CM (2014) Pflugers Arch 466: 357-367 Regulation of cyclooxygenase expression by vasopressin in rat renal medulla. Zhang MZ, Sanchez Lopez P, McKanna JA, Harris RC (2004) Endocrinology 145: 1402-9 Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage. Markadieu N, Rios K, Spiller BW, McDonald WH, Welling PA, Delpire E (2014) J Biol Chem 289: 29273-84 COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress. Moeckel GW, Zhang L, Fogo AB, Hao CM, Pozzi A, Breyer MD (2003) J Biol Chem 278: 19352-7 Intracellular granules of the renal medulla in a case of potassium depletion due to renal potassium wasting. Electron microscopic comparison with renal medullary granules in the potassium-depleted rat. France R, Gray ME, Stone WJ, Swift LL (1978) Am J Pathol 91: 299-312 High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Lewis LM, Bhave G, Chauder BA, Banerjee S, Lornsen KA, Redha R, Fallen K, Lindsley CW, Weaver CD, Denton JS (2009) Mol Pharmacol 76: 1094-103 Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS (2011) Mol Pharmacol 79: 42-50 Membrane-type 4 matrix metalloproteinase (MT4-MMP) modulates water homeostasis in mice. Srichai MB, Colleta H, Gewin L, Matrisian L, Abel TW, Koshikawa N, Seiki M, Pozzi A, Harris RC, Zent R (2011) PLoS One 6: e17099 Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells. He W, Xie Q, Wang Y, Chen J, Zhao M, Davis LS, Breyer MD, Gu G, Hao CM (2013) PLoS One 8: e79839 Anatomically-specific intratubular and interstitial biominerals in the human renal medullo-papillary complex. Chen L, Hsi RS, Yang F, Sherer BA, Stoller ML, Ho SP (2017) PLoS One 12: e0187103 Interactions between 11beta-hydroxysteroid dehydrogenase and COX-2 in kidney. Yao B, Harris RC, Zhang MZ (2005) Am J Physiol Regul Integr Comp Physiol 288: R1767-73 Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats. Meng S, Roberts LJ, Cason GW, Curry TS, Manning RD (2002) Am J Physiol Regul Integr Comp Physiol 283: R732-8 The origins of urinary stone disease: upstream mineral formations initiate downstream Randall's plaque. Hsi RS, Ramaswamy K, Ho SP, Stoller ML (2017) BJU Int 119: 177-184 Sodium-bicarbonate cotransporter NBCn1 in the kidney medullary thick ascending limb cell line is upregulated under acidic conditions and enhances ammonium transport. Lee S, Lee HJ, Yang HS, Thornell IM, Bevensee MO, Choi I (2010) Exp Physiol 95: 926-37 Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. Mernaugh RL, Yan H, Chen D, Edl J, Hanley G, Pozzi A, Zent R (2005) J Immunol Methods 306: 115-27
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.