Cellular protein synthesis and inhibition of cell division are independent of butyrate-induced histone hyperacetylation. Rubenstein P, Sealy L, Marshall S, Chalkley R (1979) Nature 280: 692-3 Cadmium is a mutagen that acts by inhibiting mismatch repair. Jin YH, Clark AB, Slebos RJ, Al-Refai H, Taylor JA, Kunkel TA, Resnick MA, Gordenin DA (2003) Nat Genet 34: 326-9 A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Cree LM, Samuels DC, de Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR, Dahl HH, Chinnery PF (2008) Nat Genet 40: 249-54 Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Gudmundsson J, Sulem P, Gudbjartsson DF, Blondal T, Gylfason A, Agnarsson BA, Benediktsdottir KR, Magnusdottir DN, Orlygsdottir G, Jakobsdottir M, Stacey SN, Sigurdsson A, Wahlfors T, Tammela T, Breyer JP, McReynolds KM, Bradley KM, Saez B, Godino J, Navarrete S, Fuertes F, Murillo L, Polo E, Aben KK, van Oort IM, Suarez BK, Helfand BT, Kan D, Zanon C, Frigge ML, Kristjansson K, Gulcher JR, Einarsson GV, Jonsson E, Catalona WJ, Mayordomo JI, Kiemeney LA, Smith JR, Schleutker J, Barkardottir RB, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K (2009) Nat Genet 41: 1122-6 What causes mitochondrial DNA deletions in human cells? Krishnan KJ, Reeve AK, Samuels DC, Chinnery PF, Blackwood JK, Taylor RW, Wanrooij S, Spelbrink JN, Lightowlers RN, Turnbull DM (2008) Nat Genet 40: 275-9 HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D (2019) Cell 176: 144-153.e13 The power of pumping together; deconstructing the engine of a DNA replication machine. Eichman BF, Fanning E (2004) Cell 119: 3-4 DNA replication through G-quadruplex motifs is promoted by the Saccharomyces cerevisiae Pif1 DNA helicase. Paeschke K, Capra JA, Zakian VA (2011) Cell 145: 678-91 Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA. Saitoh S, Chabes A, McDonald WH, Thelander L, Yates JR, Russell P (2002) Cell 109: 563-73 Regulation of transcriptional activation domain function by ubiquitin. Salghetti SE, Caudy AA, Chenoweth JG, Tansey WP (2001) Science 293: 1651-3 The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport. O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK (2017) Science 355: Hdac3 is essential for the maintenance of chromatin structure and genome stability. Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW (2010) Cancer Cell 18: 436-47 The steric hypothesis for DNA replication and fluorine hydrogen bonding revisited in light of structural data. Egli M (2012) Acc Chem Res 45: 1237-46 ETAA1 acts at stalled replication forks to maintain genome integrity. Bass TE, Luzwick JW, Kavanaugh G, Carroll C, Dungrawala H, Glick GG, Feldkamp MD, Putney R, Chazin WJ, Cortez D (2016) Nat Cell Biol 18: 1185-1195 Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Lee LA, Orr-Weaver TL (2003) Annu Rev Genet 37: 545-78 HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA (2015) Mol Cell 58: 1090-100 CLB5-dependent activation of late replication origins in S. cerevisiae. Donaldson AD, Raghuraman MK, Friedman KL, Cross FR, Brewer BJ, Fangman WL (1998) Mol Cell 2: 173-82 The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability. Dungrawala H, Rose KL, Bhat KP, Mohni KN, Glick GG, Couch FB, Cortez D (2015) Mol Cell 59: 998-1010 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Méndez J, Zou-Yang XH, Kim SY, Hidaka M, Tansey WP, Stillman B (2002) Mol Cell 9: 481-91 Checkpoint signaling from a single DNA interstrand crosslink. Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J (2009) Mol Cell 35: 704-15 Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. Kim SJ, Cox N, Courchesne R, Lord C, Corsello C, Akshoomoff N, Guter S, Leventhal BL, Courchesne E, Cook EH (2002) Mol Psychiatry 7: 278-88 Replication of N2,3-ethenoguanine by DNA polymerases. Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP (2012) Angew Chem Int Ed Engl 51: 5466-9 Murine double minute 2: p53-independent roads lead to genome instability or death. Bouska A, Eischen CM (2009) Trends Biochem Sci 34: 279-86 Mitochondrial DNA mutations in human colonic crypt stem cells. Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SJ, Greaves LC, Kirkwood TB, Turnbull DM (2003) J Clin Invest 112: 1351-60 HDAC3 is essential for DNA replication in hematopoietic progenitor cells. Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW (2013) J Clin Invest 123: 3112-23 Analysis of protein dynamics at active, stalled, and collapsed replication forks. Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D (2011) Genes Dev 25: 1320-7 SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D (2012) Genes Dev 26: 151-62 The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks. Bansbach CE, Bétous R, Lovejoy CA, Glick GG, Cortez D (2009) Genes Dev 23: 2405-14 Multiple determinants controlling activation of yeast replication origins late in S phase. Friedman KL, Diller JD, Ferguson BM, Nyland SV, Brewer BJ, Fangman WL (1996) Genes Dev 10: 1595-607 ATR phosphorylates SMARCAL1 to prevent replication fork collapse. Couch FB, Bansbach CE, Driscoll R, Luzwick JW, Glick GG, Bétous R, Carroll CM, Jung SY, Qin J, Cimprich KA, Cortez D (2013) Genes Dev 27: 1610-23 Tissue-specific and allele-specific replication timing control in the imprinted human Prader-Willi syndrome region. Gunaratne PH, Nakao M, Ledbetter DH, Sutcliffe JS, Chinault AC (1995) Genes Dev 9: 808-20 Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Elson JL, Samuels DC, Turnbull DM, Chinnery PF (2001) Am J Hum Genet 68: 802-6 Relaxed replication of mtDNA: A model with implications for the expression of disease. Chinnery PF, Samuels DC (1999) Am J Hum Genet 64: 1158-65 Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1. Brown KL, Deng JZ, Iyer RS, Iyer LG, Voehler MW, Stone MP, Harris CM, Harris TM (2006) J Am Chem Soc 128: 15188-99 Molecular basis for PrimPol recruitment to replication forks by RPA. Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ (2017) Nat Commun 8: 15222 Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. Jiang X, Klimovich V, Arunkumar AI, Hysinger EB, Wang Y, Ott RD, Guler GD, Weiner B, Chazin WJ, Fanning E (2006) EMBO J 25: 5516-26 The Schizosaccharomyces pombe cdc5+ gene encodes an essential protein with homology to c-Myb. Ohi R, McCollum D, Hirani B, Den Haese GJ, Zhang X, Burke JD, Turner K, Gould KL (1994) EMBO J 13: 471-83 A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. Mudryj M, Hiebert SW, Nevins JR (1990) EMBO J 9: 2179-84 Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. Brieba LG, Eichman BF, Kokoska RJ, Doublié S, Kunkel TA, Ellenberger T (2004) EMBO J 23: 3452-61 Endogenous DNA damage and mutation. Marnett LJ, Plastaras JP (2001) Trends Genet 17: 214-21
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