Keyword Connections

•  Angela Jefferson
•  Anne Kenworthy
•  Brandon Ally

•  Corey Hopkins
•  John Oates
•  Karoly Mirnics

•  Qi Zhang
•  Tricia Thornton-Wells

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Publications

• Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
  Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS
  (2005) Cell 120: 701-13
• Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study.
  Jefferson AL, Beiser AS, Himali JJ, Seshadri S, O'Donnell CJ, Manning WJ, Wolf PA, Au R, Benjamin EJ
  (2015) Circulation 131: 1333-9
• Cardiac index is associated with brain aging: the Framingham Heart Study.
  Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ
  (2010) Circulation 122: 690-7
• DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.
  Mirnics ZK, Mirnics K, Terrano D, Lewis DA, Sisodia SS, Schor NF
  (2003) Mol Psychiatry 8: 863-78
• Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.
  Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M
  (2017) Mol Psychiatry 22: 13-23
• Lack of a Role for Alzheimer's Disease Pathology in Late-Life Depression, or Just No Relationship With Amyloid?
  Taylor WD
  (2017) Am J Psychiatry 174: 197-198
• Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.
  Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hardy J, Hendrie HC, Hall KS, Goate AM, Lang R, Byrd GS, Kukull WA, Foroud TM, Farrer LA, Martin ER, Pericak-Vance MA, Schellenberg GD, Mayeux R, Haines JL, Thornton-Wells TA, Alzheimer Disease Genetics Consortium
  (2016) Alzheimers Dement 12: 233-43
• Commentary on "Perspective on race and ethnicity in Alzheimer's disease research".
  Griffith DM, Griffith PA
  (2008) Alzheimers Dement 4: 239-41
• Genetic modification of the relationship between phosphorylated tau and neurodegeneration.
  Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Disease Neuroimaging Initiative
  (2014) Alzheimers Dement 10: 637-645.e1
• National Institutes of Health State-of-the-Science Conference statement: preventing alzheimer disease and cognitive decline.
  Daviglus ML, Bell CC, Berrettini W, Bowen PE, Connolly ES, Cox NJ, Dunbar-Jacob JM, Granieri EC, Hunt G, McGarry K, Patel D, Potosky AL, Sanders-Bush E, Silberberg D, Trevisan M
  (2010) Ann Intern Med 153: 176-81
• Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease.
  Montine TJ, Quinn JF, Milatovic D, Silbert LC, Dang T, Sanchez S, Terry E, Roberts LJ, Kaye JA, Morrow JD
  (2002) Ann Neurol 52: 175-9
• No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls.
  Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD
  (2000) Ann Neurol 48: 950
• Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.
  Shi J, Wang Q, Johansson JU, Liang X, Woodling NS, Priyam P, Loui TM, Merchant M, Breyer RM, Montine TJ, Andreasson K
  (2012) Ann Neurol 72: 788-98
• Typical and atypical pathology in primary progressive aphasia variants.
  Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML
  (2017) Ann Neurol 81: 430-443
• Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease.
  Montine TJ, Markesbery WR, Morrow JD, Roberts LJ
  (1998) Ann Neurol 44: 410-3
• Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease.
  Smith CD, Pettigrew LC, Avison MJ, Kirsch JE, Tinkhtman AJ, Schmitt FA, Wermeling DP, Wekstein DR, Markesberry WR
  (1995) Ann Neurol 38: 194-201
• Sex differences in the genetic predictors of Alzheimer's pathology.
  Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ
  (2019) Brain 142: 2581-2589
• Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.
  Wong CW, Quaranta V, Glenner GG
  (1985) Proc Natl Acad Sci U S A 82: 8729-32
• Sex-specific genetic predictors of Alzheimer's disease biomarkers.
  Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ
  (2018) Acta Neuropathol 136: 857-872
• Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders.
  Conn PJ, Jones CK, Lindsley CW
  (2009) Trends Pharmacol Sci 30: 148-55
• Asymptomatic Alzheimer disease: Defining resilience.
  Hohman TJ, McLaren DG, Mormino EC, Gifford KA, Libon DJ, Jefferson AL, Alzheimer's Disease Neuroimaging Initiative
  (2016) Neurology 87: 2443-2450
• Women at risk for AD show increased parietal activation during a fluency task.
  Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ
  (2002) Neurology 58: 1197-202
• Progressive myoclonus epilepsy in young adults with neuropathologic features of Alzheimer's disease.
  Melanson M, Nalbantoglu J, Berkovic S, Melmed C, Andermann E, Roberts LJ, Carpenter S, Snipes GJ, Andermann F
  (1997) Neurology 49: 1732-3
• Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease.
  Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ
  (1999) Neurology 53: 1391-6
• Elevated CSF prostaglandin E2 levels in patients with probable AD.
  Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ, Morrow JD
  (1999) Neurology 53: 1495-8
• Increased CSF F2-isoprostane concentration in probable AD.
  Montine TJ, Beal MF, Cudkowicz ME, O'Donnell H, Margolin RA, McFarland L, Bachrach AF, Zackert WE, Roberts LJ, Morrow JD
  (1999) Neurology 52: 562-5
• Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study.
  Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs JB, Keaney JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C
  (2007) Neurology 68: 1032-8
• Presenilin-1-dependent transcriptome changes.
  Mirnics K, Korade Z, Arion D, Lazarov O, Unger T, Macioce M, Sabatini M, Terrano D, Douglass KC, Schor NF, Sisodia SS
  (2005) J Neurosci 25: 1571-8
• Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
  Liang X, Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K
  (2005) J Neurosci 25: 10180-7
• Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.
  Woodling NS, Wang Q, Priyam PG, Larkin P, Shi J, Johansson JU, Zagol-Ikapitte I, Boutaud O, Andreasson KI
  (2014) J Neurosci 34: 5882-94
• Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.
  Benito C, Núñez E, Tolón RM, Carrier EJ, Rábano A, Hillard CJ, Romero J
  (2003) J Neurosci 23: 11136-41
• The effect of donepezil treatment on cardiovascular mortality.
  Sato K, Urbano R, Yu C, Yamasaki F, Sato T, Jordan J, Robertson D, Diedrich A
  (2010) Clin Pharmacol Ther 88: 335-8
• Contact heat sensitivity and reports of unpleasantness in communicative people with mild to moderate cognitive impairment in Alzheimer's disease: a cross-sectional study.
  Monroe TB, Gibson SJ, Bruehl SP, Gore JC, Dietrich MS, Newhouse P, Atalla S, Cowan RL
  (2016) BMC Med 14: 74
• Genetic interactions associated with 12-month atrophy in hippocampus and entorhinal cortex in Alzheimer's Disease Neuroimaging Initiative.
  Meda SA, Koran ME, Pryweller JR, Vega JN, Thornton-Wells TA, Alzheimer's Disease Neuroimaging Initiative
  (2013) Neurobiol Aging 34: 1518.e9-18
• Interactions between GSK3β and amyloid genes explain variance in amyloid burden.
  Hohman TJ, Koran ME, Thornton-Wells TA, Alzheimer's Neuroimaging Initiative
  (2014) Neurobiol Aging 35: 460-5
• APOE genotype modifies the association between central arterial stiffening and cognition in older adults.
  Cambronero FE, Liu D, Neal JE, Moore EE, Gifford KA, Terry JG, Nair S, Pechman KR, Osborn KE, Hohman TJ, Bell SP, Sweatt JD, Wang TJ, Beckman JA, Carr JJ, Jefferson AL
  (2018) Neurobiol Aging 67: 120-127
• Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents.
  Shonesy BC, Thiruchelvam K, Parameshwaran K, Rahman EA, Karuppagounder SS, Huggins KW, Pinkert CA, Amin R, Dhanasekaran M, Suppiramaniam V
  (2012) Neurobiol Aging 33: 430.e5-18
• Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
  Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, Alzheimer's Disease Genetics Consortium
  (2016) Neurobiol Aging 38: 141-150
• Evaluating Alzheimer's disease biomarkers as mediators of age-related cognitive decline.
  Hohman TJ, Tommet D, Marks S, Contreras J, Jones R, Mungas D, Alzheimer's Neuroimaging Initiative
  (2017) Neurobiol Aging 58: 120-128
• Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease.
  SantaCruz KS, Yazlovitskaya E, Collins J, Johnson J, DeCarli C
  (2004) Neurobiol Aging 25: 63-9