The mission of the Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource (TMESCSR) is to provide services that facilitate the generation, storage and regeneration of genetically altered mice. We provide a wide array of services that are essential for the derivation, maintenance and long-term storage of genetically altered mouse models.  

The following procedures are provided on a fee-for-service basis:

  • Gene targeting in mouse ES cells
  • Pronuclear DNA microinjections
  • Recombinase Mediated Cassette Exchange
  • Embryo and sperm cryopreservation
  • In vitro fertilization and rederivation
  • BAC recombineering
  • Southern Blot Hybridization

The TMESCSR is staffed by experienced stem cell scientists and highly competent staff, and our track record in performing these services is extensive.  In addition, we are also happy to work with you to develop and/or implement new methods and techniques.  

  • Location: 9410 MRB-IV
  • Phone: 615-936-3454  
Micro-injection

Pronuclear DNA microinjection - Watch video

Management

Jennifer Skelton, MS
Managing Co-Director
Mark A. Magnuson, M.D.
Sr. Scientific Co-Director
Douglas P. Mortlock, Ph.D.
Scientific Co-Director
Susan M. Majka, PhD
Scientific Co-Director

Laboratory Personnel

Please view the TMESCSR Members page for an up to date directory.

Policies

Please view the TMESCSR Policies page for a list of policies.

Guidelines

Please view the TMESCSR Guidelines page for guidelines.

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