Mark A Magnuson, M.D.

Profile

Dr. Mark A. Magnuson is the Louise B. McGavock Professor of Molecular Physiology and Biophysics, Medicine, and Cell and Developmental Biology at Vanderbilt University. 

Dr. Magnuson graduated from Luther College in 1975 and obtained his medical degree from the University of Iowa in 1979.  He completed an internship and residency in Internal Medicine at Strong Memorial Hospital in Rochester, N.Y., followed by three years at the NIH as a Research Associate.  He came to VUMC in 1985 as both a clinical fellow in Endocrinology and a senior fellow in Molecular Physiology and Biophysics before joining the faculty in 1987. 

Dr. Magnuson has authored or co-authored over 180 peer-reviewed articles.  He has been a member of numerous scientific review panels and has served on the editorial boards for Diabetes, Molecular Endocrinology, the Journal of Biological Chemistry and the American Journal of Physiology: Endocrinology and Metabolism.  He currently chairs the Executive Committee of the Beta Cell Biology Consortium and is Associate Editor for Experimental Biology and Medicine.  In 2006 he received the Sidney P. Colowick Faculty Award at Vanderbilt.  His research has been continuously funded by the National Institutes of Health for nearly 25 years.  

Dr. Magnuson is Director of the Vanderbilt Center for Stem Cell Biology, Sr. Scientific Co-Director of the Transgenic Mouse/ES Cell Shared Resource, and Scientific Advisor for the Genome Sciences Resource.  Between 1998 and 2005 he served as Director of the Office of Biomedical Sciences and Assistant Vice Chancellor for Research.

Publications

The following timeline graph is generated from all co-authored publications.

1. The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A (2013) EMBO J
   › Primary publication · 23584530 (PubMed) · Added on 05/02/2013
2. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M (2013) Stem Cell Res 11(1): 503-515
   › Primary publication · 23562832 (PubMed) · Added on 05/02/2013
3. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M (2013) PLoS Genet 9(1): e1003274
   › Primary publication · 23382704 (PubMed) · PMC3561089 (PubMed Central) · Added on 03/19/2013
4. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV (2013) Development 140(4): 751-64
   › Primary publication · 23325761 (PubMed) · PMC3557774 (PubMed Central) · Added on 03/19/2013
5. Ghrelin expression in the mouse pancreas defines a unique multipotent progenitor population. Arnes L, Hill JT, Gross S, Magnuson MA, Sussel L (2012) PLoS One 7(12): e52026
   › Primary publication · 23251675 (PubMed) · PMC3520898 (PubMed Central) · Added on 12/28/2012
6. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM (2009) Cancer Cell 15(2): 148-59
   › Primary publication · 19185849 (PubMed) · PMC2701381 (PubMed Central) · Added on 05/27/2010
7. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA (2008) Dev Biol 316(1): 74-86
   › Primary publication · 18294628 (PubMed) · PMC2425677 (PubMed Central) · Added on 04/15/2010
8. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA (2006) Dev Cell 11(4): 583-9
   › Primary publication · 16962829 (PubMed) · Added on 05/19/2010
9. Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection. Long Q, Shelton KD, Lindner J, Jones JR, Magnuson MA (2004) Genesis 39(4): 256-62
   › Primary publication · 15286998 (PubMed) · Added on 05/27/2010
10. Allosteric activators of glucokinase: potential role in diabetes therapy. Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF (2003) Science 301(5631): 370-3
    › Primary publication · 12869762 (PubMed) · Added on 04/15/2010
11. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR (1999) Cell 96(3): 329-39
    › Primary publication · 10025399 (PubMed) · Added on 05/27/2010
12. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV (1996) Development 122(3): 983-95
    › Primary publication · 8631275 (PubMed) · Added on 05/27/2010