Patricia A Labosky, Ph.D.

Profile

Dr. Patricia A. Labosky joined the Vanderbilt Center for Stem Cell Biology (VCSCB) in September of 2006 as its second faculty recruit.  Trish earned her Ph.D. from Wesleyan University, and did her postdoctoral training here at Vanderbilt University. Previously, she was an Assistant Professor at the University of Pennsylvania.  Dr. Labosky's research focuses on studying genes that control normal development of the mammalian embryo.  In particular is the Fox family of transcription factors, such as Foxd3, which is expressed throughout the early mouse embryo, and later in multipotent neural crest cells and the pancreas.  Her studies are providing valuable new insights about the specification and maintenance of embryonic stem cells (ES Cells), and aim towards trying to understand the molecular control of stem cell fate.

Publications

The following timeline graph is generated from all co-authored publications.

1. Isolation and culture of neural crest cells from embryonic murine neural tube. Pfaltzgraff ER, Mundell NA, Labosky PA (2012) J Vis Exp (64)
   › Primary publication · 22688801 (PubMed) · Added on 07/10/2012
2. A predicted hairpin cluster correlates with barriers to PCR, sequencing and possibly BAC recombineering. Nelms BL, Labosky PA (2011) Sci Rep : 106
   › Primary publication · 22355623 (PubMed) · PMC3255507 (PubMed Central) · Added on 03/14/2012
3. Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Mundell NA, Plank JL, Legrone AW, Frist AY, Zhu L, Shin MK, Southard-Smith EM, Labosky PA (2012) Dev Biol
   › Primary publication · 22266424 (PubMed) · Added on 02/01/2012
4. Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Stam FJ, Hendricks TJ, Zhang J, Geiman EJ, Francius C, Labosky PA, Clotman F, Goulding M (2012) Development 139(1): 179-90
   › Primary publication · 22115757 (PubMed) · PMC3231776 (PubMed Central) · Added on 02/17/2012
5. Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy. Plank JL, Frist AY, LeGrone AW, Magnuson MA, Labosky PA (2011) Endocrinology 152(12): 4589-600
   › Primary publication · 21952247 (PubMed) · PMC3230055 (PubMed Central) · Added on 02/17/2012
6. Functional interaction between Foxd3 and Pax3 in cardiac neural crest development. Nelms BL, Pfaltzgraff ER, Labosky PA (2011) Genesis 49(1): 10-23
   › Primary publication · 21254333 (PubMed) · Added on 02/01/2011
7. Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Mundell NA, Labosky PA (2011) Development 138(4): 641-52
   › Primary publication · 21228004 (PubMed) · PMC3026411 (PubMed Central) · Added on 02/01/2011
8. Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation. Plank JL, Mundell NA, Frist AY, LeGrone AW, Kim T, Musser MA, Walter TJ, Labosky PA (2011) Dev Biol 349(2): 321-30
   › Primary publication · 21081123 (PubMed) · PMC3019241 (PubMed Central) · Added on 02/17/2012
9. Conditional gene targeting in mouse pancreatic {beta}-cells: Analysis of ectopic Cre transgene expression in the brain. Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MM, Gannon M, Powers AC, Dempsey PJ (2010) Diabetes
   › Primary publication · 20802254 (PubMed) · Added on 09/04/2010
10. Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage. Liber D, Domaschenz R, Holmqvist PH, Mazzarella L, Georgiou A, Leleu M, Fisher AG, Labosky PA, Dillon N (2010) Cell Stem Cell 7(1): 114-26
    › Primary publication · 20621055 (PubMed) · Added on 08/02/2010
11. Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors. Misfeldt AM, Boyle SC, Tompkins KL, Bautch VL, Labosky PA, Baldwin HS (2009) Dev Biol 333(1): 78-89
    › Primary publication · 19576203 (PubMed) · Added on 04/07/2010
12. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, Christian SL, Mancini G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA (2009) Brain 132(Pt 6): 1563-76
    › Primary publication · 19439424 (PubMed) · PMC2685924 (PubMed Central) · Added on 06/11/2010
13. Mouse primordial germ cells: isolation and in vitro culture. Labosky PA, Hogan BL (2008) Methods Mol Biol : 187-99
    › Primary publication · 19030797 (PubMed) · Added on 04/07/2010
14. Identification of Arx transcriptional targets in the developing basal forebrain. Fulp CT, Cho G, Marsh ED, Nasrallah IM, Labosky PA, Golden JA (2008) Hum Mol Genet 17(23): 3740-60
    › Primary publication · 18799476 (PubMed) · PMC2581427 (PubMed Central) · Added on 06/11/2010
15. Regulation of ES Cell Self Renewal and Pluripotency by Foxd3. Liu Y, Labosky PA (2008) Stem Cells
    › Primary publication · 18653770 (PubMed) · Added on 04/07/2010
16. Requirement for Foxd3 in the maintenance of neural crest progenitors. Teng L, Mundell NA, Frist AY, Wang Q, Labosky PA (2008) Development 135(9): 1615-24
    › Primary publication · 18367558 (PubMed) · Added on 04/07/2010
17. A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X. Tai SJ, Herzog RW, Margaritis P, Arruda VR, Chu K, Golden JA, Labosky PA, High KA (2008) J Thromb Haemost 6(2): 339-45
    › Primary publication · 18036190 (PubMed) · PMC2471867 (PubMed Central) · Added on 06/11/2010
18. Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis. Grenier G, Scimè A, Le Grand F, Asakura A, Perez-Iratxeta C, Andrade-Navarro MA, Labosky PA, Rudnicki MA (2007) Stem Cells 25(12): 3101-10
    › Primary publication · 17823241 (PubMed) · Added on 06/11/2010
19. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP (2007) Development 134(18): 3327-38
    › Primary publication · 17720696 (PubMed) · Added on 06/11/2010
20. FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Steiner AB, Engleka MJ, Lu Q, Piwarzyk EC, Yaklichkin S, Lefebvre JL, Walters JW, Pineda-Salgado L, Labosky PA, Kessler DS (2006) Development 133(24): 4827-38
    › Primary publication · 17092955 (PubMed) · Added on 04/07/2010
21. Neural crest stem cells. Teng L, Labosky PA (2006) Adv Exp Med Biol : 206-12
    › Primary publication · 17076284 (PubMed) · Added on 04/07/2010
22. Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas. Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA (2006) Gene Expr Patterns 6(8): 971-7
    › Primary publication · 16750430 (PubMed) · Added on 04/07/2010
23. HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B (2006) Genes Dev 20(5): 557-70
    › Primary publication · 16510872 (PubMed) · PMC1410808 (PubMed Central) · Added on 06/11/2010
24. Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo. Tompers DM, Foreman RK, Wang Q, Kumanova M, Labosky PA (2005) Dev Biol 285(1): 126-37
    › Primary publication · 16039639 (PubMed) · Added on 04/07/2010
25. A dermal niche for multipotent adult skin-derived precursor cells. Fernandes KJ, McKenzie IA, Mill P, Smith KM, Akhavan M, Barnabé-Heider F, Biernaskie J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD (2004) Nat Cell Biol 6(11): 1082-93
    › Primary publication · 15517002 (PubMed) · Added on 06/11/2010
26. Electroporation of murine embryonic stem cells: a step-by-step guide. Tompers DM, Labosky PA (2004) Stem Cells 22(3): 243-9
    › Primary publication · 15153600 (PubMed) · Added on 04/07/2010
27. Online with stem cells. Labosky PA (2003) Dev Cell 5(6): 827-8
    › Primary publication · 14667405 (PubMed) · Added on 06/11/2010
28. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA (2002) Genes Dev 16(20): 2650-61
    › Primary publication · 12381664 (PubMed) · Added on 04/07/2010
29. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Katz JP, Perreault N, Goldstein BG, Lee CS, Labosky PA, Yang VW, Kaestner KH (2002) Development 129(11): 2619-28
    › Primary publication · 12015290 (PubMed) · PMC2225535 (PubMed Central) · Added on 06/11/2010
30. The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate. Dottori M, Gross MK, Labosky P, Goulding M (2001) Development 128(21): 4127-38
    › Primary publication · 11684651 (PubMed) · Added on 06/16/2011
31. The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex. Kloetzli JM, Fontaine-Glover IA, Brown ER, Kuo M, Labosky PA (2001) Genesis 29(2): 60-71
    › Primary publication · 11170346 (PubMed) · Added on 06/11/2010
32. Mesendoderm induction and reversal of left-right pattern by mouse Gdf1, a Vg1-related gene. Wall NA, Craig EJ, Labosky PA, Kessler DS (2000) Dev Biol 227(2): 495-509
    › Primary publication · 11071769 (PubMed) · Added on 06/11/2010
33. BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest. Kanzler B, Foreman RK, Labosky PA, Mallo M (2000) Development 127(5): 1095-104
    › Primary publication · 10662648 (PubMed) · Added on 04/07/2010
34. The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development. Labosky PA, Kaestner KH (1998) Mech Dev 76(1-2): 185-90
    › Primary publication · 9767163 (PubMed) · Added on 04/07/2010
35. A role for Indian hedgehog in extraembryonic endoderm differentiation in F9 cells and the early mouse embryo. Becker S, Wang ZJ, Massey H, Arauz A, Labosky P, Hammerschmidt M, St-Jacques B, Bumcrot D, McMahon A, Grabel L (1997) Dev Biol 187(2): 298-310
    › Primary publication · 9242425 (PubMed) · Added on 06/16/2011
36. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Wilson CL, Heppner KJ, Labosky PA, Hogan BL, Matrisian LM (1997) Proc Natl Acad Sci U S A 94(4): 1402-7
    › Primary publication · 9037065 (PubMed) · PMC19803 (PubMed Central) · Added on 06/11/2010
37. Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. Suzuki N, Labosky PA, Furuta Y, Hargett L, Dunn R, Fogo AB, Takahara K, Peters DM, Greenspan DS, Hogan BL (1996) Development 122(11): 3587-95
    › Primary publication · 8951074 (PubMed) · Added on 06/11/2010
38. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Zhao GQ, Deng K, Labosky PA, Liaw L, Hogan BL (1996) Genes Dev 10(13): 1657-69
    › Primary publication · 8682296 (PubMed) · Added on 06/11/2010
39. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T (1995) J Clin Invest 96(6): 2947-54
    › Primary publication · 8675666 (PubMed) · PMC186006 (PubMed Central) · Added on 06/11/2010
40. The chromosomal mapping of four genes encoding winged helix proteins expressed early in mouse development. Labosky PA, Winnier GE, Sasaki H, Blessing M, Hogan BL (1996) Genomics 34(2): 241-5
    › Primary publication · 8661058 (PubMed) · Added on 06/11/2010
41. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV (1996) Development 122(3): 983-95
    › Primary publication · 8631275 (PubMed) · Added on 06/11/2010
42. Homeobox-containing genes in teratocarcinoma embryoid bodies: a possible role for Hox-D12 (Hox-4.7) in establishing the extraembryonic endoderm lineage in the mouse. Labosky PA, Weir MP, Grabel LB (1993) Dev Biol 159(1): 232-44
    › Primary publication · 8103490 (PubMed) · Added on 06/11/2010
43. The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development. Lin TP, Labosky PA, Grabel LB, Kozak CA, Pitman JL, Kleeman J, MacLeod CL (1994) Dev Biol 166(1): 170-9
    › Primary publication · 7958444 (PubMed) · Added on 06/11/2010
44. Embryonic germ cell lines and their derivation from mouse primordial germ cells. Labosky PA, Barlow DP, Hogan BL (1994) Ciba Found Symp : 157-68; discussion 168-78
    › Primary publication · 7835148 (PubMed) · Added on 06/11/2010
45. Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. Labosky PA, Barlow DP, Hogan BL (1994) Development 120(11): 3197-204
    › Primary publication · 7720562 (PubMed) · Added on 06/11/2010
46. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Winnier G, Blessing M, Labosky PA, Hogan BL (1995) Genes Dev 9(17): 2105-16
    › Primary publication · 7657163 (PubMed) · Added on 06/11/2010
47. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BL, Inagami T (1995) Nature 377(6551): 748-50
    › Primary publication · 7477267 (PubMed) · Added on 06/11/2010