The mission of the Vanderbilt Center for Stem Cell Biology is to learn more about the biology of stem cells and mechanisms for directing their differentiation to specific cell fates.
Embryonic stem cells are able to differentiate into any of the many different cell types found in the body. A great deal remains to be learned about them, and how to convert them into various tissue and cell types that can be used to treat a variety of human diseases.
The Vanderbilt Center for Stem Cell Biology is home for the Coordinating Center for the Beta Cell Biology Consortium. A major goal of this consortium of scientists is to learn how to make pancreatic beta cells, which are destroyed in Type 1 diabetes, from embryonic stem cells.
- Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Sparks EE, Huppert KA, Brown MA, Washington MK, Huppert SS (2010) Hepatology 51(4): 1391-400
› Primary publication · 20069650 (PubMed) · Added on 04/10/2010
- New complexity in differentiating stem cells toward hepatic and pancreatic fates. Huppert SS, Magnuson MA (2009) Sci Signal 2(83): pe50
› Primary publication · 19671927 (PubMed) · Added on 04/10/2010
- Endocardial cells are a distinct endothelial lineage derived from Flk1+ multipotent cardiovascular progenitors. Misfeldt AM, Boyle SC, Tompkins KL, Bautch VL, Labosky PA, Baldwin HS (2009) Dev Biol 333(1): 78-89
› Primary publication · 19576203 (PubMed) · Added on 04/10/2010
- Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G (2009) Proc Natl Acad Sci U S A 106(24): 9715-20
› Primary publication · 19487660 (PubMed) · PMC2701002 (PubMed Central) · Added on 04/10/2010
- mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM (2009) Cancer Cell 15(2): 148-59
› Primary publication · 19185849 (PubMed) · PMC2701381 (PubMed Central) · Added on 04/10/2010
- Requirement for Foxd3 in the maintenance of neural crest progenitors. Teng L, Mundell NA, Frist AY, Wang Q, Labosky PA (2008) Development 135(9): 1615-24
› Primary publication · 18367558 (PubMed) · PMC2562748 (PubMed Central) · Added on 04/10/2010
- Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA (2008) Dev Biol 316(1): 74-86
› Primary publication · 18294628 (PubMed) · PMC2425677 (PubMed Central) · Added on 04/10/2010
- pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV (2008) Dev Biol 314(2): 406-17
› Primary publication · 18155690 (PubMed) · PMC2269701 (PubMed Central) · Added on 04/10/2010
- Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G (2007) Mech Dev 124(11-12): 898-910
› Primary publication · 17928203 (PubMed) · PMC2141686 (PubMed Central) · Added on 04/10/2010