Profile

Dr. Mortlock is Research Assistant Professor in the Center for Human Genetics Research (CHGR) and the Departments of Molecular Physiology and Biophysics, and Pediatrics, in the Vanderbilt University School of Medicine.   He has extensive expertise in mouse and human genetic mapping and disease gene cloning, mammalian developmental biology, gene structure, transgenic models, and gene expression analysis.  He has specific expertise in expression and function of BMP family genes in animal development and has pioneered the study of long-range cis-regulatory elements that control expression of the Gdf6, Bmp2 and Bmp4 genes and in particular, the regulation of Bmp2 in ossifying tissues.  He has done pioneering studies with engineered BAC constructs to study gene expression in animal models and cell lines.  He has technical expertise in analyzing in vivo and in vitro gene expression including luciferase assays, transgene expression and function, mouse genetics, genotyping and molecular biology, mouse embryology and histology, and osteoblast development.  As co-director of the Transgenic Mouse / ES Cell Shared Resource, he provides review oversight for new project applications and also operates the BAC Recombineering and blot hybridization services for the TMESCSR.    

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Recurrent Tissue-Specific mtDNA Mutations Are Common in Humans. Samuels DC, Li C, Li B, Song Z, Torstenson E, Boyd Clay H, Rokas A, Thornton-Wells TA, Moore JH, Hughes TM, Hoffman RD, Haines JL, Murdock DG, Mortlock DP, Williams SM (2013) PLoS Genet 9(11): e1003929
    › Primary publication · 24244193 (PubMed) · PMC3820769 (PubMed Central)
  2. Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM (2013) Development 140(22): 4574-82
    › Primary publication · 24154528 (PubMed) · PMC3817943 (PubMed Central)
  3. Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells. Marsell R, Steen B, Bais MV, Mortlock DP, Einhorn TA, Gerstenfeld LC (2014) J Orthop Res 32(1): 17-23
    › Primary publication · 24018651 (PubMed)
  4. Acute BMP2 upregulation following induction of ischemic osteonecrosis in immature femoral head. Kamiya N, Shafer S, Oxendine I, Mortlock DP, Chandler RL, Oxburgh L, Kim HK (2013) Bone 53(1): 239-47
    › Primary publication · 23219944 (PubMed)
  5. The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. Clendenning DE, Mortlock DP (2012) PLoS One 7(5): e36789
    › Primary publication · 22693558 (PubMed) · PMC3365063 (PubMed Central)
  6. UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice. Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M (2012) Mol Cell Biol 32(12): 2312-22
    › Primary publication · 22493062 (PubMed) · PMC3372261 (PubMed Central)
  7. Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis. Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, Gerstenfeld LC (2012) Bone 51(1): 168-80
    › Primary publication · 22391215 (PubMed) · PMC3719967 (PubMed Central)
  8. Identifying functional annotation for noncoding genomic sequences. Mortlock DP, Pregizer S (2012) Curr Protoc Hum Genet : Unit1.10
    › Primary publication · 22241655 (PubMed)
  9. Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar. Reed NP, Mortlock DP (2010) Dev Dyn 239(4): 1047-60
    › Primary publication · 20201106 (PubMed)
  10. Control of BMP gene expression by long-range regulatory elements. Pregizer S, Mortlock DP (2009) Cytokine Growth Factor Rev 20(5-6): 509-15
    › Primary publication · 19900834 (PubMed) · PMC2787762 (PubMed Central)
  11. Identification of an ancient Bmp4 mesoderm enhancer located 46 kb from the promoter. Chandler KJ, Chandler RL, Mortlock DP (2009) Dev Biol 327(2): 590-602
    › Primary publication · 19159624 (PubMed) · PMC2846791 (PubMed Central)
  12. Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression. Chandler KJ, Chandler RL, Broeckelmann EM, Hou Y, Southard-Smith EM, Mortlock DP (2007) Mamm Genome 18(10): 693-708
    › Primary publication · 17882484 (PubMed) · PMC3110064 (PubMed Central)
  13. Assessing the functional characteristics of synonymous and nonsynonymous mutation candidates by use of large DNA constructs. Eeds AM, Mortlock D, Wade-Martins R, Summar ML (2007) Am J Hum Genet 80(4): 740-50
    › Primary publication · 17357079 (PubMed) · PMC1852709 (PubMed Central)
  14. Bmp2 transcription in osteoblast progenitors is regulated by a distant 3' enhancer located 156.3 kilobases from the promoter. Chandler RL, Chandler KJ, McFarland KA, Mortlock DP (2007) Mol Cell Biol 27(8): 2934-51
    › Primary publication · 17283059 (PubMed) · PMC1899916 (PubMed Central)

Featured Affiliations

  • Mortlock Lab
    Assistant Professor of Molecular Physiology & Biop
View all affiliations

Contact Information

519 Light Hall Center for Human Genetics Research
2215 Garland Avenue
Nashville, TN 37232-0700
United States
615-936-1671 (p)
615-343-8619 (f)
Email

Keywords

genomics (5), developmental biology (12), human (1), transcription factors (3), Gdf6 (1), Bmp4 (1), long-range gene regulation (1), enhancers (1), bone and joint development (1), mouse and zebrafish genetics (1), BAC transgenes (1), Bmp2 (1)