Dr. Mortlock is Research Assistant Professor in the Center for Human Genetics Research (CHGR) and the Departments of Molecular Physiology and Biophysics, and Pediatrics, in the Vanderbilt University School of Medicine. He has extensive expertise in mouse and human genetic mapping and disease gene cloning, mammalian developmental biology, gene structure, transgenic models, and gene expression analysis. He has specific expertise in expression and function of BMP family genes in animal development and has pioneered the study of long-range cis-regulatory elements that control expression of the Gdf6, Bmp2 and Bmp4 genes and in particular, the regulation of Bmp2 in ossifying tissues. He has done pioneering studies with engineered BAC constructs to study gene expression in animal models and cell lines. He has technical expertise in analyzing in vivo and in vitro gene expression including luciferase assays, transgene expression and function, mouse genetics, genotyping and molecular biology, mouse embryology and histology, and osteoblast development. As co-director of the Transgenic Mouse / ES Cell Shared Resource, he provides review oversight for new project applications and also operates the BAC Recombineering and blot hybridization services for the TMESCSR.
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